Target Details
| UniProt AC | O60674 |
|---|---|
| Gene Symbol | JAK2 |
| Protein Name | Tyrosine-protein kinase JAK2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 10,545
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (26)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Herpes simplex virus 1 infection
- Hormone signaling
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Necroptosis
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toxoplasmosis
- Tuberculosis
Associated Diseases (9)
Active Molecules (10,545)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OQDGVIXOMPQWQW
|
10.1 | IC50 | 2 | — | |
PCMFBOQFEWOWIY
|
10.1 | Ki | 2 | — | |
QPZAYQIDTOLOAC
|
10.1 | IC50 | 2 | — | |
QRORYECTXLINFG
|
10.1 | Ki | 2 | — | |
RGYINCLTDOJACX
|
10.1 | IC50 | 2 | — | |
RKCWWRVQGOCAKM
|
10.1 | IC50 | 2 | — | |
SNNXBVPXCIVTOK
|
10.1 | IC50 | 2 | — | |
VCCJOVKEVJPDTQ
|
10.1 | IC50 | 2 | — | |
WJAGYFYDSQXEDC
|
10.1 | Ki | 2 | — | |
ZEMKOQGKMADMOM
|
10.1 | IC50 | 2 | — | |
WRFANJMETRKSFA
|
10.1 | IC50 | 4 | — | |
GCRPKZFLZHBPJI
|
10.1 | IC50 | 2 | — | |
NKIGZOJXNGMDHT
|
10.1 | IC50 | 2 | — | |
CJXPNZXEEPSZHK
|
10.1 | Ki | 5 | — | |
KYGMSHBHSDBHRQ
|
10.1 | IC50 | 2 | — | |
CQAQZMPRLYALAL
|
10.1 | IC50 | 2 | — | |
FNPKYQXNXFNZBN
|
10.1 | IC50 | 2 | — | |
FYTBERZHHUHMHE
|
10.1 | Ki | 2 | — | |
JDWOLUFDUIWNHJ
|
10.1 | Ki | 2 | — | |
UKWNKVMCKCUSLW
|
10.1 | Ki | 2 | — | |
WFBYDUIMMVFPLN
|
10.1 | IC50 | 2 | — | |
XIPYVIOWRGYLFI
|
10.1 | IC50 | 2 | — | |
YRCARAFDWIAWJL
|
10.1 | Ki | 2 | — | |
ZGTGVGIFPHRGJP
|
10.1 | IC50 | 2 | — | |
VMYNMIVIUVJIHY
|
10.0 | IC50 | 2 | — | |
YEMGRNZLFUZGTR
|
10.0 | IC50 | 2 | — | |
AKKMNVYVOCEDET
|
10.0 | Ki | 2 | — | |
BLVCWVSYQABHSB
|
10.0 | Ki | 2 | — | |
DQSILYTXROORLC
|
10.0 | Ki | 2 | — | |
GCNDXXSIOIKPLV
|
10.0 | IC50 | 2 | — | |
GCYXDKSMPIBYTR
|
10.0 | Ki | 2 | — | |
GUVNMXUCKBQQCC
|
10.0 | IC50 | 2 | — | |
JKXFWUICTJJOMR
|
10.0 | Ki | 2 | — | |
MONOVCADVPANKP
|
10.0 | IC50 | 2 | — | |
OUFHYGMICYVPJO
|
10.0 | Ki | 2 | — | |
PAAXNRZNSVJLOA
|
10.0 | IC50 | 2 | — | |
QRZRGWMGZPUVIL
|
10.0 | IC50 | 2 | — | |
URQPTYCGJISVTD
|
10.0 | Ki | 2 | — | |
URVFJVXEAYRVCV
|
10.0 | Ki | 4 | — | |
XUBODOZNSMBJOD
|
10.0 | IC50 | 4 | — | |
YCMGUXRIFKZINL
|
10.0 | IC50 | 2 | — | |
YPWJXZWSFKFYJI
|
10.0 | Ki | 2 | — | |
YRUGLQYFJCJTQM
|
10.0 | Ki | 2 | — | |
HJWYZAOXQLPRRD
|
10.0 | IC50 | 2 | — | |
LJGKJOABCDCQLE
|
10.0 | IC50 | 4 | — | |
UWHIGIGJYWQVAR
|
10.0 | IC50 | 3 | — | |
FPLDLCFSEQHYEF
|
10.0 | IC50 | 4 | — | |
GKMDQFMGAVLZKR
|
10.0 | IC50 | 2 | — | |
IRWSLAXPNKLGLH
|
10.0 | Ki | 2 | — | |
LKWGXMHPDZPNBK
|
10.0 | IC50 | 3 | — |