Target Details
| UniProt AC | O60674 |
|---|---|
| Gene Symbol | JAK2 |
| Protein Name | Tyrosine-protein kinase JAK2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 10,545
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (26)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Herpes simplex virus 1 infection
- Hormone signaling
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Necroptosis
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toxoplasmosis
- Tuberculosis
Associated Diseases (9)
Active Molecules (10,545)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZCYLZFOHMVLJNQ
|
10.3 | IC50 | 2 | — | |
ZFQPKPKMLYGAEJ
|
10.3 | IC50 | 2 | — | |
ZGNJQOOBOYTFHA
|
10.3 | IC50 | 2 | — | |
ZJAQVPWGBNUWLT
|
10.3 | IC50 | 2 | — | |
ZPDSAXFDGQBXKL
|
10.3 | IC50 | 2 | — | |
ZZWSVWLKMJYUAE
|
10.3 | IC50 | 2 | — | |
ZZWSVWLKMJYUAE
|
10.3 | IC50 | 2 | — | |
AYSPNZYVJHZGIG
|
10.2 | Ki | 4 | — | |
PDOGAEAFDICXFC
|
10.2 | IC50 | 2 | — | |
UVWWSVLFELMDEN
|
10.2 | IC50 | 2 | — | |
DUNMNNOSTARHFC
|
10.2 | Ki | 2 | — | |
FCWDCSBCUQREKU
|
10.2 | Ki | 2 | — | |
FIWZXYWXBGFQSA
|
10.2 | Ki | 2 | — | |
FIXODQLYPRSTCO
|
10.2 | Ki | 4 | — | |
FIXODQLYPRSTCO
|
10.2 | Ki | 4 | — | |
FOIOAHKFRGNAMO
|
10.2 | Ki | 2 | — | |
HWMOTJVQQAVGFN
|
10.2 | Ki | 2 | — | |
IUSHFHFQXQXSQX
|
10.2 | IC50 | 2 | — | |
KBUFRYLIBNBLOU
|
10.2 | Ki | 2 | — | |
KZDKKBCVTWYPRV
|
10.2 | IC50 | 2 | — | |
MLUQXJNMRUQORU
|
10.2 | Ki | 2 | — | |
OICGZDBPQBIFLV
|
10.2 | IC50 | 2 | — | |
ROUUBNNTZMLFCL
|
10.2 | Ki | 2 | — | |
WNVSABGLXFTXRN
|
10.2 | Ki | 2 | — | |
RKDYFKWEFAJOHF
|
10.2 | IC50 | 4 | — | |
IMMLXIZVTUKHEQ
|
10.2 | Ki | 4 | — | |
ACXRPKBVTFNUBE
|
10.2 | IC50 | 4 | — | |
SMPSLOLOVXFPCR
|
10.2 | IC50 | 2 | — | |
DVIAOMWIMTUTBT
|
10.2 | IC50 | 2 | — | |
LNTSTFPYHHHPLZ
|
10.2 | IC50 | 4 | — | |
ZPMOMQNJSGBBAD
|
10.2 | IC50 | 2 | — | |
WWJGFVVXHNAPOB
|
10.2 | IC50 | 2 | — | |
BNOPEBHGDTWAQX
|
10.2 | IC50 | 4 | — | |
GLQQQPJQXUIPOL
|
10.2 | Ki | 2 | — | |
HHNQUSKCERMSSB
|
10.2 | Ki | 2 | — | |
JMHWBBCPKDYGSF
|
10.2 | Ki | 4 | — | |
KHCFKCPXXJQHMH
|
10.2 | Ki | 5 | — | |
LUXSOKJTOICWHQ
|
10.2 | IC50 | 2 | — | |
YKTNKWVDICOPMZ
|
10.2 | IC50 | 2 | — | |
AVZLKLPFHIKARU
|
10.1 | IC50 | 2 | — | |
HKZKUYDLAQQSJQ
|
10.1 | Ki | 2 | — | |
JQGRGIAYUIEXHU
|
10.1 | IC50 | 2 | — | |
SXFUYVYSIDXMPH
|
10.1 | IC50 | 2 | — | |
YKBQLVVJJHUKDV
|
10.1 | IC50 | 2 | — | |
DKBFFMKIJKBAMH
|
10.1 | Ki | 4 | — | |
QHRMQKJISSPTFZ
|
10.1 | IC50 | 2 | — | |
HICJIUGQVXQINW
|
10.1 | Ki | 2 | — | |
LBFQOESLJMTEIV
|
10.1 | Ki | 2 | — | |
LIWWZPGNFLTTAB
|
10.1 | Ki | 2 | — | |
ODWRWZLATYVRLY
|
10.1 | Ki | 2 | — |