Target Details
| UniProt AC | O60674 |
|---|---|
| Gene Symbol | JAK2 |
| Protein Name | Tyrosine-protein kinase JAK2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 10,545
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (26)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Herpes simplex virus 1 infection
- Hormone signaling
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Necroptosis
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toxoplasmosis
- Tuberculosis
Associated Diseases (9)
Active Molecules (10,545)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FNYKNWAPYCCIQE
|
10.4 | IC50 | 3 | — | |
GOZFKFAFAJSLCX
|
10.4 | IC50 | 2 | — | |
MXDGOCGSIURVTR
|
10.4 | IC50 | 2 | — | |
BIUZUMXNKSQCFI
|
10.4 | Ki | 4 | — | |
DWSHMTRKCGSRHM
|
10.4 | Ki | 4 | — | |
FVNKMSONBLQBNG
|
10.4 | IC50 | 3 | — | |
JWZIADYHSJEHSW
|
10.4 | IC50 | 2 | — | |
KQAJQVQIWBQIFM
|
10.4 | Ki | 4 | — | |
MDGKQKHJTRCFKH
|
10.4 | IC50 | 2 | — | |
MDGKQKHJTRCFKH
|
10.4 | IC50 | 2 | — | |
NHEWAADAROXBHT
|
10.4 | Ki | 2 | — | |
QCGBDTSLOLLHEJ
|
10.4 | Ki | 4 | — | |
QCGBDTSLOLLHEJ
|
10.4 | Ki | 4 | — | |
RYVTYSVONAMCBS
|
10.4 | Ki | 4 | — | |
SSLGYCGYZMIQJD
|
10.4 | IC50 | 2 | — | |
UNKLRGOHFNDILM
|
10.4 | Ki | 2 | — | |
UWZLUJZCOIATJC
|
10.4 | Ki | 4 | — | |
VMYNMIVIUVJIHY
|
10.4 | IC50 | 2 | — | |
YBAFPAFESOTFOQ
|
10.4 | IC50 | 2 | — | |
PRVFLAJYZAQPNR
|
10.4 | IC50 | 3 | — | |
HBJWGPOVAOVPGD
|
10.4 | IC50 | 2 | — | |
KFPFHFNFCCTGOO
|
10.4 | IC50 | 4 | — | |
MNLRALLJFYLNRI
|
10.4 | IC50 | 2 | — | |
PPDRYWDVANCHFT
|
10.3 | Ki | 4 | — | |
ROCWQSCNNATQOY
|
10.3 | Ki | 4 | — | |
SQPIIYGBMFSLFR
|
10.3 | IC50 | 2 | — | |
UXPYEJLTPMRCCL
|
10.3 | IC50 | 2 | — | |
TTWJGJUDRLYONZ
|
10.3 | Kd | 6 | — | |
AQGDWJQZAICCQE
|
10.3 | IC50 | 2 | — | |
GQAYABNMBBTJFN
|
10.3 | IC50 | 2 | — | |
AXLSAJBAFIAJCA
|
10.3 | IC50 | 2 | — | |
BCMIRTHEUWYNHX
|
10.3 | IC50 | 4 | — | |
CNLCAZXJGQVMJI
|
10.3 | Ki | 2 | — | |
FTQBYQRDFCFCFN
|
10.3 | Ki | 4 | — | |
KTCIAOLTOISTRF
|
10.3 | Ki | 2 | — | |
PDUVQCXXOZUIED
|
10.3 | IC50 | 2 | — | |
PTYZWRDJQNYYOD
|
10.3 | Ki | 2 | — | |
PXTMUXZHALRTHU
|
10.3 | Ki | 2 | — | |
QHXCXCRTHJNOIR
|
10.3 | IC50 | 2 | — | |
UYRGIZHUWUTGEG
|
10.3 | Ki | 2 | — | |
BRDKHBSREKWDRJ
|
10.3 | IC50 | 2 | — | |
DJUAJWMTCKJXRM
|
10.3 | Kd | 4 | — | |
JOKKEFYHRTWHHC
|
10.3 | Ki | 4 | — | |
MNLRALLJFYLNRI
|
10.3 | IC50 | 3 | — | |
AIWAMXKDRXZMII
|
10.3 | IC50 | 3 | — | |
ATKQNWIMTWIHAX
|
10.3 | IC50 | 2 | — | |
AXTDVIWQOAOLOG
|
10.3 | IC50 | 2 | — | |
BEULMSQGFTWTJJ
|
10.3 | IC50 | 2 | — | |
BMYVGSNMQZIKOG
|
10.3 | IC50 | 2 | — | |
BNAASPOSNZYKHH
|
10.3 | IC50 | 2 | — |