Target Details
| UniProt AC | O60674 |
|---|---|
| Gene Symbol | JAK2 |
| Protein Name | Tyrosine-protein kinase JAK2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 10,545
- Clinical molecules 78
- Avg pChEMBL 7.81
KEGG Pathways (26)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Herpes simplex virus 1 infection
- Hormone signaling
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Necroptosis
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toxoplasmosis
- Tuberculosis
Associated Diseases (9)
Active Molecules (10,545)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NCZZXIYJRYNEAO
|
11.4 | IC50 | 3 | — | |
PLALKTRHBMUZHB
|
11.1 | IC50 | 3 | — | |
AUWLNQDLZOSAFU
|
11.1 | IC50 | 2 | — | |
CYEYGIKHGQVFKY
|
11.0 | IC50 | 2 | — | |
NONQHXZJSJTQSM
|
11.0 | IC50 | 2 | — | |
GPOGKSDOWYRIMA
|
10.9 | Ki | 4 | — | |
PJTVQALTARBQFE
|
10.9 | Ki | 4 | — | |
WIICDYUXOKRMJM
|
10.9 | Ki | 4 | — | |
KAVVKRQBEAWLIE
|
10.8 | Ki | 4 | — | |
RNWGSYOIILQORV
|
10.8 | Ki | 4 | — | |
QMHIFZZTSBMKGF
|
10.8 | IC50 | 3 | — | |
JCYROZOHYWKFQS
|
10.8 | IC50 | 2 | — | |
LKYNKWVSJBBRNP
|
10.8 | Ki | 4 | — | |
RUGKMJBVTQEPHN
|
10.7 | IC50 | 2 | — | |
OKNGBMISBWKGAC
|
10.7 | IC50 | 2 | — | |
AMQJRDKUJJLKCK
|
10.7 | Ki | 4 | — | |
BAHITJWCHBRYNZ
|
10.7 | Ki | 4 | — | |
BNFKFVISRQDWHB
|
10.7 | IC50 | 2 | — | |
GYZPAKVHBCQCKK
|
10.7 | IC50 | 3 | — | |
KAHARENCCCTWSQ
|
10.7 | Ki | 4 | — | |
PLOAUINIELSVFC
|
10.7 | Ki | 4 | — | |
YAHQISLGSOFLRU
|
10.7 | Ki | 4 | — | |
XNDQNBFQNOZWQD
|
10.7 | IC50 | 2 | — | |
HACRCBAIIDXXCJ
|
10.7 | IC50 | 2 | — | |
SBOGQLBMEWOYIL
|
10.6 | IC50 | 2 | — | |
AMBGBDGUUYGEJS
|
10.6 | Ki | 4 | — | |
IOVFFTMQWCOHDE
|
10.6 | Ki | 4 | — | |
RINWDSCUVKTALQ
|
10.6 | Ki | 4 | — | |
YEMGRNZLFUZGTR
|
10.6 | IC50 | 2 | — | |
BWZWPXZXRGUPNX
|
10.5 | IC50 | 2 | — | |
NONQHXZJSJTQSM
|
10.5 | IC50 | 2 | — | |
VNDHJWSNDHLJRC
|
10.5 | IC50 | 2 | — | |
BPENMBMNYYAYNC
|
10.5 | Ki | 4 | — | |
CQVLTKQROAIZOC
|
10.5 | Ki | 4 | — | |
DFAZSOUFLNOONE
|
10.5 | Ki | 4 | — | |
DFAZSOUFLNOONE
|
10.5 | Ki | 4 | — | |
JXVIBSHMZHZTST
|
10.5 | IC50 | 3 | — | |
NPXRGBHWBLKOFJ
|
10.5 | Ki | 4 | — | |
OIHUOYBHLAZFLD
|
10.5 | Ki | 4 | — | |
QHHRTNNXPWXSMX
|
10.5 | Ki | 4 | — | |
UUVRCVXQRKLYNN
|
10.5 | Ki | 4 | — | |
UUVRCVXQRKLYNN
|
10.5 | Ki | 4 | — | |
KZPCATSDOZHYDA
|
10.5 | Ki | 4 | — | |
LXCJYFUAMDZSGA
|
10.5 | Ki | 4 | — | |
ODJLPNCPBKODCN
|
10.5 | Ki | 4 | — | |
VQIIUJSNIKEMCK
|
10.5 | Ki | 4 | — | |
VVUPFHUSDJLFEM
|
10.5 | Ki | 4 | — | |
GEBIRRZRZLCAHK
|
10.5 | IC50 | 2 | — | |
MCRCGCWWWPPTGL
|
10.5 | Kd | 4 | — | |
SNVFGNBQSYUPIG
|
10.5 | IC50 | 2 | — |