Target Details
| UniProt AC | O60603 |
|---|---|
| Gene Symbol | TLR2 |
| Protein Name | Toll-like receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00560 (LRR_1) PF13855 (LRR_8) PF01463 (LRRCT) PF01582 (TIR) |
Summary
- Multi-target molecules 14
- Clinical molecules 0
- Avg pChEMBL 6.24
KEGG Pathways (23)
- Amoebiasis
- Chagas disease
- Coronavirus disease - COVID-19
- Epstein-Barr virus infection
- Hepatitis B
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- Inflammatory bowel disease
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- Malaria
- Measles
- Neutrophil extracellular trap formation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Phagosome
- Proteoglycans in cancer
- Rheumatoid arthritis
- Salmonella infection
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
Associated Diseases (2)
Active Molecules (14)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
LITXVDAFEYLWQE
|
7.3 | IC50 | 2 | — | |
QDMWTNUZGRPLNU
|
6.5 | IC50 | 2 | — | |
CFPIBJMMFYBQTH
|
6.4 | IC50 | 3 | — | |
DZCYGXRMSXMTSC
|
6.3 | IC50 | 3 | — | |
IOVUIBJPWGTRGS
|
6.3 | IC50 | 2 | — | |
WRBCJFIKTXONAZ
|
6.2 | IC50 | 3 | — | |
YDZVFBDCUXVBDN
|
6.2 | IC50 | 2 | — | |
YVXGWCCIBZMQEC
|
6.2 | IC50 | 2 | — | |
FTGAKYZOANSYNW
|
6.1 | IC50 | 2 | — | |
BFDXAFCWAUVMSC
|
6.0 | IC50 | 3 | — | |
LLLQWYGRBDZJLI
|
6.0 | IC50 | 2 | — | |
IBUNWGCPQRDSJW
|
6.0 | IC50 | 2 | — | |
MZBPJXCTMRNEKE
|
6.0 | IC50 | 3 | — | |
SNHQEEKVWMSJHE
|
6.0 | IC50 | 2 | — |