Target Details
| UniProt AC | O43318 |
|---|---|
| Gene Symbol | MAP3K7 |
| Protein Name | Mitogen-activated protein kinase kinase kinase 7 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 178
- Clinical molecules 12
- Avg pChEMBL 6.96
KEGG Pathways (29)
- AMPK signaling pathway
- Adherens junction
- Alcoholic liver disease
- Autophagy - animal
- Coronavirus disease - COVID-19
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- Hepatitis B
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- Leishmaniasis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neutrophil extracellular trap formation
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- RIG-I-like receptor signaling pathway
- Salmonella infection
- Shigellosis
- T cell receptor signaling pathway
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Wnt signaling pathway
- Yersinia infection
Associated Diseases (2)
Active Molecules (178)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FEKDFTQZRBQDGS
|
6.2 | IC50 | 4 | — | |
JMWLMRFTIKZMEL
|
6.2 | IC50 | 2 | — | |
QYZOGCMHVIGURT
|
6.2 | Kd | 26 | Yes | |
JJSAYYGWZQRZJC
|
6.2 | IC50 | 2 | — | |
DQEKCEBMQCYICP
|
6.2 | Ki | 3 | — | |
MLDQJTXFUGDVEO
|
6.2 | Kd | 85 | Yes | |
KSTJUKWFMNVLEG
|
6.2 | IC50 | 2 | — | |
HFNKQEVNSGCOJV
|
6.1 | Kd | 65 | — | |
QTEPTJGEVYOFFX
|
6.1 | IC50 | 2 | — | |
ZZSBPGIGIUFJRA
|
6.1 | Kd | 46 | — | |
RLTVBHOYTGZPMF
|
6.1 | IC50 | 2 | — | |
LBBOLBNLXHDGBI
|
6.1 | IC50 | 2 | — | |
PNQHSKHLOWEBAN
|
6.1 | IC50 | 2 | — | |
DBLRPUYTBFIYCV
|
6.1 | IC50 | 2 | — | |
IEOZVBDPTHRYGK
|
6.1 | Ki | 3 | — | |
YTNYGYHAAUCRGR
|
6.1 | IC50 | 2 | — | |
CMOPUHDFFUAOMA
|
6.1 | Ki | 11 | Yes | |
KDIQGWYECCPTCS
|
6.1 | IC50 | 2 | — | |
QPZICBYPSUODET
|
6.1 | IC50 | 2 | — | |
LMSVUVDUKNLKGS
|
6.0 | IC50 | 2 | — | |
QSGQYRLKAVRIDE
|
6.0 | IC50 | 2 | — | |
CARBIKJGHPINLY
|
6.0 | IC50 | 2 | — | |
HCBIATVCCJRSKR
|
6.0 | IC50 | 5 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
PYNBJKLUOZMGRV
|
6.0 | IC50 | 2 | — | |
SFXNZFNSPSLHEA
|
6.0 | IC50 | 2 | — |