Target Details
| UniProt AC | O15530 |
|---|---|
| Gene Symbol | PDPK1 |
| Protein Name | 3-phosphoinositide-dependent protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF14593 (PH_3) PF00069 (Pkinase) |
Summary
- Multi-target molecules 228
- Clinical molecules 49
- Avg pChEMBL 7.12
KEGG Pathways (27)
- AMPK signaling pathway
- Aldosterone-regulated sodium reabsorption
- Apoptosis
- Autophagy - animal
- Axon guidance
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Endometrial cancer
- Fc epsilon RI signaling pathway
- Focal adhesion
- FoxO signaling pathway
- IgSF CAM signaling
- Insulin resistance
- Insulin signaling pathway
- Lipid and atherosclerosis
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- PPAR signaling pathway
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Toxoplasmosis
- mTOR signaling pathway
Active Molecules (228)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JUSSXPRFOJRUEO
|
7.2 | IC50 | 2 | — | |
NDIUYMHNCUTVGE
|
7.2 | Ki | 25 | — | |
YEIVLMDWYXFKHN
|
7.1 | IC50 | 3 | Yes | |
PLZWVXKEQYGKTJ
|
7.1 | IC50 | 7 | Yes | |
FUWKNYZEQAGYBA
|
7.1 | IC50 | 3 | Yes | |
GCBJDOWIQHMCMR
|
7.1 | Ki | 84 | — | |
MASJMHFQMYAPJR
|
7.1 | Ki | 41 | — | |
MIKAKZKNMYZLDX
|
7.1 | Ki | 42 | — | |
MVJMMLFMPWITEJ
|
7.1 | Ki | 110 | — | |
RJZDECGDCKOHBV
|
7.1 | Ki | 70 | — | |
RKKIDHHGKNGTQI
|
7.1 | Ki | 28 | — | |
VVKMHTWFAUCCOD
|
7.1 | IC50 | 2 | — | |
LELXPYUUIHYFLJ
|
7.0 | IC50 | 2 | — | |
LOQFJHOTUSHCJC
|
7.0 | IC50 | 2 | — | |
GUCKMVSSUAFQHI
|
7.0 | IC50 | 2 | — | |
WTXOBVPDUBTCKU
|
7.0 | IC50 | 2 | — | |
ZHOWANFERDNTSO
|
7.0 | IC50 | 5 | Yes | |
JZSOIKWBCKPKSW
|
7.0 | IC50 | 2 | — | |
NTOPCHNZZCMHKE
|
7.0 | IC50 | 2 | — | |
UQSUHZYCCQIWGQ
|
7.0 | IC50 | 2 | — | |
VUHZDNOPEVGHEO
|
7.0 | Ki | 29 | — | |
ZLHFILGSQDJULK
|
7.0 | Ki | 37 | Yes | |
BGFOEUFOBZQIEL
|
7.0 | IC50 | 2 | — | |
RJJPYOHCKJYJPH
|
7.0 | IC50 | 2 | — | |
CXLNZTRSMVEOOL
|
7.0 | IC50 | 2 | — | |
SUCAWRZDHHYRQV
|
7.0 | IC50 | 2 | — | |
NHHQJBCNYHBUSI
|
6.9 | Kd | 220 | — | |
CQRFXINTEFATOH
|
6.9 | IC50 | 2 | Yes | |
HABRRQSUPGOZTD
|
6.9 | IC50 | 3 | Yes | |
JZOJBOMGNJTZMY
|
6.9 | IC50 | 2 | Yes | |
OLUKILHGKRVDCT
|
6.9 | Ki | 44 | Yes | |
TVLFEDKEAOXRCZ
|
6.9 | Ki | 22 | — | |
QNABDSWBQJKBHK
|
6.9 | IC50 | 45 | — | |
VDDFCDUWOMCJQP
|
6.9 | IC50 | 2 | — | |
JPILNANJKLSYFG
|
6.8 | IC50 | 2 | — | |
AKBDTDXHGVXZLY
|
6.8 | IC50 | 4 | — | |
LYNBNVBMAGDJRW
|
6.8 | Ki | 81 | — | |
NZVDDFRUBIEKLV
|
6.8 | Ki | 20 | — | |
RIXHCYHQTKRWDU
|
6.8 | IC50 | 4 | Yes | |
XYZNKCSDQRKAFR
|
6.8 | Ki | 53 | — | |
BMGQWWVMWDBQGC
|
6.7 | Kd | 147 | Yes | |
BMGQWWVMWDBQGC
|
6.7 | Kd | 91 | Yes | |
MKSQRGQNPZBVPP
|
6.7 | IC50 | 4 | — | |
NQVSRBQAHLEDFP
|
6.7 | IC50 | 3 | Yes | |
UMTWTCVTRDYHQQ
|
6.7 | Ki | 56 | — | |
RFPGSBIVMOJECN
|
6.7 | IC50 | 2 | — | |
HFNJWNHCEQNJQQ
|
6.6 | IC50 | 6 | — | |
WAJYOJVNNBMVIM
|
6.6 | IC50 | 6 | Yes | |
WSCBMCCISYODBR
|
6.6 | IC50 | 3 | — | |
YJCWUJKWNBKVAH
|
6.6 | IC50 | 2 | — |