Target Details
| UniProt AC | O15530 |
|---|---|
| Gene Symbol | PDPK1 |
| Protein Name | 3-phosphoinositide-dependent protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF14593 (PH_3) PF00069 (Pkinase) |
Summary
- Multi-target molecules 228
- Clinical molecules 49
- Avg pChEMBL 7.12
KEGG Pathways (27)
- AMPK signaling pathway
- Aldosterone-regulated sodium reabsorption
- Apoptosis
- Autophagy - animal
- Axon guidance
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Endometrial cancer
- Fc epsilon RI signaling pathway
- Focal adhesion
- FoxO signaling pathway
- IgSF CAM signaling
- Insulin resistance
- Insulin signaling pathway
- Lipid and atherosclerosis
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- PPAR signaling pathway
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Toxoplasmosis
- mTOR signaling pathway
Active Molecules (228)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZWSYVXUTWLOAGF
|
7.8 | IC50 | 2 | — | |
ZZSBPGIGIUFJRA
|
7.8 | Kd | 46 | — | |
GAMJJHMLLXIWRZ
|
7.8 | IC50 | 4 | Yes | |
GCYXEGSPUDSZJY
|
7.8 | Ki | 82 | — | |
RYYNGWLOYLRZLK
|
7.8 | Ki | 104 | — | |
VYUCXCHYYRTQIX
|
7.8 | IC50 | 2 | — | |
XNXUJUXYVTYIGP
|
7.8 | IC50 | 3 | — | |
SOVOJYOIAXOTIM
|
7.7 | IC50 | 3 | — | |
YPVWKNICBVIRFI
|
7.7 | IC50 | 2 | — | |
JIJYWPGTRDMEFZ
|
7.7 | IC50 | 5 | Yes | |
LYADGAGFYYXXIO
|
7.7 | IC50 | 82 | — | |
NCMNSDQGHJLYTB
|
7.7 | IC50 | 3 | — | |
NCSQDKMOKNQGSG
|
7.7 | IC50 | 3 | Yes | |
VNDWQCSOSCCWIP
|
7.7 | IC50 | 39 | Yes | |
YMIJUBCSOKSFRU
|
7.7 | Ki | 87 | — | |
SOZLQZRDILXEMY
|
7.7 | IC50 | 2 | — | |
WEKPBIWDHVJAHJ
|
7.7 | IC50 | 3 | — | |
PCTRICLZSMFSET
|
7.7 | IC50 | 4 | Yes | |
HVNQYDHDQBJAAH
|
7.6 | IC50 | 2 | Yes | |
REJNNNBQXIZBJP
|
7.6 | IC50 | 2 | — | |
XROQQHOCADBSBW
|
7.5 | IC50 | 2 | — | |
RBOZDIXMEJGUHI
|
7.5 | IC50 | 2 | — | |
CQRFXINTEFATOH
|
7.5 | IC50 | 2 | Yes | |
MBIMERRBQGQJIO
|
7.5 | IC50 | 6 | — | |
OXICUMLYVMEXBW
|
7.4 | IC50 | 2 | — | |
HAWIAGQHDCBUDW
|
7.4 | IC50 | 2 | — | |
IYCLDXCYBZSIAQ
|
7.4 | IC50 | 2 | — | |
JZTOUVBEZONDKA
|
7.4 | Ki | 80 | — | |
SDWFSRDARUDGGP
|
7.4 | IC50 | 2 | — | |
YIUCWIKVMNKNTC
|
7.3 | IC50 | 2 | — | |
BSFNGHCTZDCQBF
|
7.3 | Ki | 93 | — | |
CKVWQORGCCEYHS
|
7.3 | Ki | 50 | — | |
FLEAYYMORDPWAJ
|
7.3 | Ki | 90 | — | |
HVNQYDHDQBJAAH
|
7.3 | IC50 | 3 | Yes | |
LDKHTALMQVJDPD
|
7.3 | IC50 | 4 | Yes | |
OUJZYQBEFNDJQN
|
7.3 | Ki | 71 | — | |
UOVCGJXDGOGOCZ
|
7.3 | Ki | 59 | — | |
WYOMXSAYYXBPMN
|
7.3 | Ki | 24 | — | |
GSANTMGDHXCBLR
|
7.3 | IC50 | 2 | — | |
JPOSFPUHBHRUAX
|
7.3 | IC50 | 40 | Yes | |
UEFCSGDOOJJXTN
|
7.3 | IC50 | 46 | — | |
UKOYDWAFPPPEKW
|
7.3 | IC50 | 2 | — | |
QLCDVXBLLOIZEO
|
7.2 | IC50 | 2 | Yes | |
SNUCYAQWRAUYRP
|
7.2 | IC50 | 2 | — | |
TZOLUHQWLXJGBH
|
7.2 | IC50 | 7 | Yes | |
BBRFDCSUZSLLHO
|
7.2 | IC50 | 2 | — | |
NVINUNQBDNEMSY
|
7.2 | IC50 | 4 | — | |
SOCBMSNYZZANAU
|
7.2 | IC50 | 2 | — | |
LBQOBBCURKRQJV
|
7.2 | IC50 | 2 | — | |
YUJACPUEEGUFHA
|
7.2 | IC50 | 3 | Yes |