Target Details
| UniProt AC | O15530 |
|---|---|
| Gene Symbol | PDPK1 |
| Protein Name | 3-phosphoinositide-dependent protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF14593 (PH_3) PF00069 (Pkinase) |
Summary
- Multi-target molecules 228
- Clinical molecules 49
- Avg pChEMBL 7.12
KEGG Pathways (27)
- AMPK signaling pathway
- Aldosterone-regulated sodium reabsorption
- Apoptosis
- Autophagy - animal
- Axon guidance
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Endometrial cancer
- Fc epsilon RI signaling pathway
- Focal adhesion
- FoxO signaling pathway
- IgSF CAM signaling
- Insulin resistance
- Insulin signaling pathway
- Lipid and atherosclerosis
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- PPAR signaling pathway
- Platinum drug resistance
- Prostate cancer
- Proteoglycans in cancer
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Toxoplasmosis
- mTOR signaling pathway
Active Molecules (228)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IRUKUIBQFXFZTM
|
9.2 | Ki | 3 | Yes | |
YXZBQCQAYNRRFP
|
9.2 | Ki | 3 | Yes | |
BPVKBARHCLRGKI
|
9.0 | Ki | 3 | Yes | |
HKSZLNNOFSGOKW
|
8.9 | Ki | 118 | — | |
GBNXVWADDOZSLG
|
8.9 | Ki | 3 | Yes | |
LRZYYIZFBXFSJB
|
8.8 | Ki | 69 | — | |
HKSZLNNOFSGOKW
|
8.8 | Kd | 213 | — | |
RXQBATCWIIRYFZ
|
8.6 | Ki | 3 | Yes | |
CFWZNCTWCNPULR
|
8.5 | IC50 | 3 | — | |
HKSZLNNOFSGOKW
|
8.5 | IC50 | 408 | — | |
OBAJYVJLNXGBOG
|
8.5 | IC50 | 3 | — | |
PHJGKALEAVCXAU
|
8.5 | IC50 | 3 | — | |
PNBXRRJXVOABCN
|
8.5 | IC50 | 2 | — | |
UIARLYUEJFELEN
|
8.5 | Kd | 289 | Yes | |
ANTIKNNFTURTLK
|
8.4 | IC50 | 2 | — | |
AWQLNADWVBCMHO
|
8.3 | IC50 | 2 | — | |
KKXKMMGAGIUIAK
|
8.3 | IC50 | 3 | — | |
NXUWGUQHCIIYBD
|
8.3 | IC50 | 2 | — | |
PANBKHQUCFTTQA
|
8.3 | IC50 | 2 | — | |
WIWPGJGLUKQUKV
|
8.3 | IC50 | 2 | — | |
CFWZNCTWCNPULR
|
8.2 | IC50 | 3 | — | |
DFURSNCTQGJRRX
|
8.2 | IC50 | 3 | — | |
DRPJZMIFBAXAKX
|
8.2 | IC50 | 3 | — | |
PHJGKALEAVCXAU
|
8.2 | IC50 | 3 | — | |
UUQADGWFQPYANC
|
8.2 | IC50 | 3 | — | |
VAVXGGRQQJZYBL
|
8.2 | IC50 | 8 | — | |
ZWSYVXUTWLOAGF
|
8.2 | IC50 | 3 | — | |
IJNGXROUMFEKDB
|
8.1 | Ki | 39 | — | |
JHTBKNDSXPZVBM
|
8.1 | IC50 | 3 | — | |
NXSJMRCTGYTSTK
|
8.1 | Kd | 200 | — | |
OSVUGUHRKMMBSE
|
8.1 | Kd | 170 | — | |
OWRXHGAFWZFFCW
|
8.1 | Ki | 113 | — | |
XNXUJUXYVTYIGP
|
8.1 | IC50 | 3 | — | |
YHWXSMVLIYQGKB
|
8.1 | IC50 | 3 | — | |
FGVBXWYMYMNXGE
|
8.1 | IC50 | 4 | Yes | |
HTFVUONILLSIET
|
8.1 | IC50 | 2 | — | |
TUJPTADWUUEJPE
|
8.1 | IC50 | 2 | — | |
YBRYILPNEOTARN
|
8.1 | IC50 | 2 | — | |
DASFSPDIWCMVRW
|
8.0 | Ki | 21 | — | |
DUCXJHSBLDKCIK
|
8.0 | IC50 | 2 | — | |
QLPHOXTXAKOFMU
|
8.0 | IC50 | 2 | — | |
DLUFUVCAUGKHRL
|
8.0 | IC50 | 2 | — | |
LLKFNPUXQZHIAE
|
8.0 | IC50 | 2 | — | |
PFPJHXYCUWHBHV
|
8.0 | IC50 | 2 | — | |
DMMILYKXNCVKOJ
|
7.9 | IC50 | 3 | — | |
VWVYILCFSYNJHF
|
7.9 | Ki | 49 | — | |
WEKPBIWDHVJAHJ
|
7.9 | IC50 | 3 | — | |
RULBQJYTXYLQOK
|
7.9 | IC50 | 2 | — | |
YPVWKNICBVIRFI
|
7.8 | IC50 | 3 | — | |
OBAJYVJLNXGBOG
|
7.8 | IC50 | 3 | — |