Target Details
| UniProt AC | O15264 |
|---|---|
| Gene Symbol | MAPK13 |
| Protein Name | Mitogen-activated protein kinase 13 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 533
- Clinical molecules 10
- Avg pChEMBL 7.2
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (533)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VRSHGZMFXJHCDY
|
6.8 | IC50 | 5 | — | |
HFQBEBGFOOARGT
|
6.8 | IC50 | 4 | — | |
AIZGSJRXZMRUPZ
|
6.8 | IC50 | 4 | — | |
BPLTVYXMXOYIBK
|
6.8 | IC50 | 9 | — | |
COXXCKLSWHHFDS
|
6.8 | IC50 | 5 | — | |
GCDPHNDMHYQIDA
|
6.8 | IC50 | 4 | — | |
QUZUYBVTTGUAGJ
|
6.8 | IC50 | 5 | — | |
SLEDJBMFRMKJLH
|
6.8 | IC50 | 5 | — | |
FQYLJBVSYHZWLT
|
6.8 | Ki | 35 | Yes | |
HKSZLNNOFSGOKW
|
6.8 | IC50 | 408 | — | |
MVJMMLFMPWITEJ
|
6.8 | Ki | 110 | — | |
NCECUPUQFBKLMA
|
6.8 | IC50 | 5 | — | |
NGFGTMFVWSDFPS
|
6.8 | IC50 | 32 | — | |
WHUWKNHDIBNFLZ
|
6.8 | IC50 | 4 | — | |
UKIUUWZOERDVQU
|
6.8 | IC50 | 4 | — | |
WFDFOPHPWGDOIZ
|
6.8 | IC50 | 4 | — | |
FRZNJFWQVYAVCE
|
6.8 | Kd | 4 | — | |
NKKDRSDFMZYYCB
|
6.8 | IC50 | 6 | — | |
VXPWQNBKEIVYIS
|
6.8 | IC50 | 4 | — | |
WDYHPKURZUGMIN
|
6.8 | IC50 | 4 | — | |
ZHYLCLLSWFBKEF
|
6.8 | IC50 | 4 | — | |
XCTLHQGUEQKAQS
|
6.8 | IC50 | 4 | — | |
ATDCPRWAKIBWOH
|
6.8 | IC50 | 4 | — | |
HEYLBNKMXMMHAM
|
6.8 | IC50 | 4 | — | |
MSPJXCARRAHCLI
|
6.8 | IC50 | 4 | — | |
RASGAWVMUIIYGF
|
6.8 | IC50 | 4 | — | |
YYQUGNLGTLHJFO
|
6.8 | IC50 | 6 | — | |
MAOSUPNJVJGJEU
|
6.7 | IC50 | 5 | — | |
PLUFSXPPGWXWEZ
|
6.7 | IC50 | 4 | — | |
RAWYMBACZSQNDD
|
6.7 | IC50 | 4 | — | |
RYBDMKKIZXATSX
|
6.7 | IC50 | 5 | — | |
SVDHANHLZJVQLK
|
6.7 | IC50 | 4 | — | |
UKFXLFGOLVTDOY
|
6.7 | IC50 | 4 | — | |
ZBHQRYHFJRDCMN
|
6.7 | IC50 | 4 | — | |
CJKGORBZVWDVRY
|
6.7 | IC50 | 4 | — | |
CYBPFCXTRADFRZ
|
6.7 | IC50 | 4 | — | |
HKSZLNNOFSGOKW
|
6.7 | Ki | 118 | — | |
IVEKGMPDASLCAJ
|
6.7 | IC50 | 4 | — | |
KKYPRNBBPBRJQX
|
6.7 | Ki | 40 | — | |
OPGDQKHWHCHXQH
|
6.7 | Kd | 4 | — | |
PIVXVZXCGYSMHO
|
6.7 | IC50 | 4 | — | |
URTATIJPBIRPTP
|
6.7 | IC50 | 4 | — | |
WFRLFWGASBLYTC
|
6.7 | IC50 | 15 | Yes | |
WIULXZIMZXTPDW
|
6.7 | IC50 | 4 | — | |
WPDIHFNVASUBFE
|
6.7 | IC50 | 4 | — | |
XOOAAYRIVATZNM
|
6.7 | Ki | 55 | — | |
YMNCVRSYJBNGLD
|
6.7 | IC50 | 4 | — | |
QADVIGAMUTUMMC
|
6.7 | IC50 | 4 | — | |
UTJPXFUHWFHNCZ
|
6.7 | IC50 | 6 | — | |
ZTCSEBJFMIAPGW
|
6.7 | IC50 | 4 | — |