Target Details
| UniProt AC | O15264 |
|---|---|
| Gene Symbol | MAPK13 |
| Protein Name | Mitogen-activated protein kinase 13 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 533
- Clinical molecules 10
- Avg pChEMBL 7.2
KEGG Pathways (65)
- AGE-RAGE signaling pathway in diabetic complications
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Efferocytosis
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- MAPK signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Oocyte meiosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Proteoglycans in cancer
- RIG-I-like receptor signaling pathway
- Rap1 signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
Active Molecules (533)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JATKIRZRXGKMBU
|
6.1 | IC50 | 4 | — | |
AYKRXRVXSJGBJP
|
6.1 | IC50 | 4 | — | |
SFTNVXWKNHSZDN
|
6.1 | Kd | 4 | — | |
UPYYEIHAZSVKFD
|
6.1 | IC50 | 4 | — | |
BSFNGHCTZDCQBF
|
6.1 | Ki | 93 | — | |
FAYAUAZLLLJJGH
|
6.1 | Ki | 36 | Yes | |
IGNVZQCPQGZXSY
|
6.1 | IC50 | 4 | — | |
IJNGXROUMFEKDB
|
6.1 | Ki | 39 | — | |
JCFJQIHDZHHMQT
|
6.1 | Ki | 42 | — | |
MLGGUGPIWDHBAI
|
6.1 | Ki | 33 | — | |
PXRDIWAVNLQFBI
|
6.1 | IC50 | 6 | Yes | |
TXFGEKSPLVPFLN
|
6.1 | IC50 | 4 | — | |
AJIGCFPKVZIIGA
|
6.1 | IC50 | 4 | — | |
IAAZVAITVNPXCO
|
6.1 | IC50 | 5 | — | |
YNBVKQXDDAWGKI
|
6.1 | IC50 | 4 | — | |
KRRCAAGRJZQAMA
|
6.0 | IC50 | 4 | — | |
OGGGFMZSNXIFQY
|
6.0 | IC50 | 4 | — | |
RPSRGHSCASYFGD
|
6.0 | IC50 | 4 | — | |
HDUQKBUHXYJBEX
|
6.0 | IC50 | 5 | — | |
JUCVIQPUESHERW
|
6.0 | IC50 | 4 | — | |
MMIOYPRRBPIXJS
|
6.0 | IC50 | 4 | — | |
LHDHGTQRVCVMKJ
|
6.0 | IC50 | 5 | — | |
ADMFLILDQJSEIK
|
6.0 | Ki | 72 | — | |
ASWWEASHSSNEMM
|
6.0 | IC50 | 4 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KCKXYZOBGBJZEG
|
6.0 | Ki | 36 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
LGHBDVLAHHANMX
|
6.0 | Ki | 53 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
QSXGIABTGIJOJX
|
6.0 | IC50 | 4 | — | |
RASYCTOLUDYCNH
|
6.0 | IC50 | 4 | — | |
XQOXBLZAGOVRCZ
|
6.0 | IC50 | 4 | — | |
XSDJOIOVIMPMHD
|
6.0 | Ki | 44 | — |