Target Details
| UniProt AC | O15111 |
|---|---|
| Gene Symbol | CHUK |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18397 (IKBKB_SDD) PF12179 (IKKbetaNEMObind) PF00069 (Pkinase) |
Summary
- Multi-target molecules 170
- Clinical molecules 16
- Avg pChEMBL 6.72
KEGG Pathways (54)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (2)
Active Molecules (170)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CTEHMRUJZDTSPT
|
6.4 | IC50 | 2 | — | |
WONYOHLOECXBDY
|
6.4 | IC50 | 2 | — | |
BSFNGHCTZDCQBF
|
6.4 | Ki | 93 | — | |
DCEAJJZHQFOWRL
|
6.4 | IC50 | 3 | — | |
FJPFKKDTDZRSIR
|
6.4 | IC50 | 2 | — | |
HWADPPKZZYESMF
|
6.4 | IC50 | 2 | — | |
XJLFMRGTLRIXDT
|
6.4 | IC50 | 2 | — | |
UOVILLRJCVEGLB
|
6.4 | IC50 | 2 | — | |
APRXYRORERCWAV
|
6.4 | IC50 | 2 | — | |
WESZAXMBDDQWNG
|
6.4 | IC50 | 2 | — | |
VBFOQJUDSYRBDR
|
6.3 | IC50 | 2 | — | |
JQFFORXNDDEBAU
|
6.3 | IC50 | 2 | — | |
MFZZZRBZKVFGHR
|
6.3 | IC50 | 4 | Yes | |
NKGLJTITEFZKAN
|
6.3 | Ki | 35 | — | |
RHPZNJJJKFQSAG
|
6.3 | IC50 | 3 | — | |
USHMNZBDAOGLMB
|
6.3 | Ki | 26 | — | |
WHJZGZLLYCQKOO
|
6.3 | IC50 | 3 | — | |
NESVCOQUFDGZKO
|
6.3 | IC50 | 2 | — | |
WINHZLLDWRZWRT
|
6.3 | Kd | 201 | Yes | |
NMQGPYPYJSEVSC
|
6.3 | IC50 | 4 | Yes | |
QKKIWEILHCXECO
|
6.2 | IC50 | 24 | — | |
GTOXTYNPQZEAIY
|
6.2 | IC50 | 4 | Yes | |
BWZCCEYPZOYICS
|
6.2 | IC50 | 2 | — | |
NNJUNDLQIUBFIU
|
6.2 | IC50 | 2 | — | |
RFVBRKXQYUDGIO
|
6.2 | Ki | 23 | — | |
SGHXFHRRWFLILP
|
6.2 | Ki | 29 | — | |
VSEFBGXIMFQPOP
|
6.2 | IC50 | 2 | — | |
CTNPALGJUAXMMC
|
6.2 | Kd | 151 | — | |
MDTKQKJDAXYFCW
|
6.2 | IC50 | 2 | — | |
YFSYLICIZSSYBB
|
6.2 | IC50 | 2 | — | |
HWIDIXYYYBFSPD
|
6.2 | IC50 | 2 | — | |
BEGWCMAELGWWIV
|
6.1 | IC50 | 2 | — | |
IPILWECSKGVOIC
|
6.1 | IC50 | 2 | — | |
ARAKMVRBBTWPJZ
|
6.1 | IC50 | 2 | — | |
FMIIOKMEEXTVQD
|
6.1 | IC50 | 2 | — | |
FNMOTKZHZAEQQF
|
6.1 | IC50 | 2 | — | |
HAFBRQDBRQDCSQ
|
6.1 | IC50 | 2 | — | |
JLXHKQDBDWGYJH
|
6.1 | IC50 | 2 | — | |
LBJKDVWECYXKJZ
|
6.1 | IC50 | 3 | — | |
RULRLUFVKXIRNZ
|
6.1 | IC50 | 2 | — | |
UISYHKUAFRQWRK
|
6.1 | IC50 | 2 | — | |
YUOWJICKAJQZLS
|
6.1 | Ki | 35 | — | |
LCGRALYGJXIQKN
|
6.1 | IC50 | 2 | — | |
BYMRVDVGQVMXFP
|
6.1 | IC50 | 2 | — | |
JOOXLOJCABQBSG
|
6.1 | Kd | 139 | — | |
GEAPVWOLRPIXJU
|
6.1 | IC50 | 2 | — | |
RJBNLDIMJDGXNV
|
6.1 | IC50 | 2 | — | |
UMGOIQFASVFXBU
|
6.1 | IC50 | 2 | — | |
AAFMUTYTWRBOGE
|
6.0 | IC50 | 2 | — | |
MEXOVCGPGSMZQQ
|
6.0 | IC50 | 2 | — |