Target Details
| UniProt AC | O15111 |
|---|---|
| Gene Symbol | CHUK |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18397 (IKBKB_SDD) PF12179 (IKKbetaNEMObind) PF00069 (Pkinase) |
Summary
- Multi-target molecules 170
- Clinical molecules 16
- Avg pChEMBL 6.72
KEGG Pathways (54)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (2)
Active Molecules (170)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NHHQJBCNYHBUSI
|
6.9 | Kd | 220 | — | |
CDNQNPSWFHDZDZ
|
6.9 | IC50 | 2 | — | |
JTOAKYPOVGNGDU
|
6.9 | IC50 | 3 | — | |
PQNZVSVIDDXJQO
|
6.9 | IC50 | 3 | — | |
QMYPKGGBVVCXIE
|
6.9 | IC50 | 3 | — | |
RJZDECGDCKOHBV
|
6.9 | Ki | 70 | — | |
SXUNZFYJEHXSOJ
|
6.9 | IC50 | 3 | — | |
UWDMHLZUTCJHIF
|
6.9 | IC50 | 2 | — | |
SZBKUUYQNSJGMR
|
6.9 | IC50 | 2 | — | |
PPHJGMVOOBKFEI
|
6.8 | IC50 | 2 | — | |
IZGQPLWVVNTXJB
|
6.8 | IC50 | 2 | — | |
VAYBIKAXZPWVBH
|
6.8 | IC50 | 2 | — | |
AUHMLXFXJCNEMM
|
6.8 | IC50 | 2 | — | |
LZOJZUJTDLMDSH
|
6.8 | IC50 | 2 | — | |
PSLDQEIGOZTJMS
|
6.8 | IC50 | 3 | — | |
SFFKUECRLQXXTN
|
6.8 | IC50 | 3 | — | |
SOIQVEVFDNZKNF
|
6.8 | IC50 | 3 | — | |
VJODYKRXQHPRCX
|
6.8 | IC50 | 2 | — | |
VUTLUBADCGINEP
|
6.8 | IC50 | 3 | — | |
ZFUNSBXCLHVTOY
|
6.8 | IC50 | 2 | — | |
YYLKKYCXAOBSRM
|
6.7 | Kd | 191 | — | |
ILOYIIQDZQBDDS
|
6.7 | IC50 | 2 | — | |
BFXYIBREKSWTFK
|
6.7 | IC50 | 2 | — | |
CHZVFENZCVWBMI
|
6.7 | IC50 | 2 | — | |
RJXLKDFSBJOHBM
|
6.7 | IC50 | 4 | Yes | |
XMLJHUDPEAJQOK
|
6.7 | IC50 | 2 | — | |
YITXQMHAQVCANR
|
6.7 | IC50 | 3 | — | |
ALNKZWZEELZRCE
|
6.7 | IC50 | 5 | Yes | |
ZAUQKMTUOLGTHT
|
6.7 | IC50 | 2 | — | |
APRXYRORERCWAV
|
6.6 | IC50 | 2 | — | |
UOQMKZIYNRHZEF
|
6.6 | IC50 | 2 | — | |
WVAGWWGCPIPVSM
|
6.6 | IC50 | 2 | — | |
CHILCFMQWMQVAL
|
6.6 | IC50 | 6 | — | |
DYVFBWXIOCLHPP
|
6.6 | IC50 | 2 | — | |
HNQXYQNMPSACKT
|
6.6 | IC50 | 4 | — | |
NLUPJKQOKWBWFC
|
6.6 | Ki | 69 | — | |
ZEVAYPOLTQWGHH
|
6.6 | IC50 | 2 | — | |
ILOYIIQDZQBDDS
|
6.6 | IC50 | 2 | — | |
MCGRFOSDZZVTTO
|
6.6 | IC50 | 2 | — | |
SOFBJAGASYHSSD
|
6.6 | IC50 | 2 | — | |
BWZJBXAPRCVCKQ
|
6.5 | IC50 | 5 | Yes | |
HBKASJKFEFLCPR
|
6.5 | IC50 | 2 | — | |
LDGNCLMLMHSOCB
|
6.5 | IC50 | 2 | — | |
NFGNAZKUHXHPNH
|
6.5 | IC50 | 2 | — | |
NZANNALXDKRTAW
|
6.5 | IC50 | 2 | — | |
YWTBGJGMTBHQTM
|
6.5 | Ki | 65 | — | |
GOTKZROZHBWZJH
|
6.5 | IC50 | 6 | — | |
MAFLHOXURZCIKH
|
6.5 | IC50 | 2 | — | |
MXCVCAHPICGSHU
|
6.5 | IC50 | 2 | — | |
BNRXMSGHPVYSDK
|
6.5 | IC50 | 24 | — |