Target Details
| UniProt AC | O15111 |
|---|---|
| Gene Symbol | CHUK |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18397 (IKBKB_SDD) PF12179 (IKKbetaNEMObind) PF00069 (Pkinase) |
Summary
- Multi-target molecules 170
- Clinical molecules 16
- Avg pChEMBL 6.72
KEGG Pathways (54)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (2)
Active Molecules (170)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UREBDLICKHMUKA
|
9.3 | IC50 | 13 | — | |
QBYYCHRRPPTEBG
|
8.2 | IC50 | 2 | — | |
RAJZSJJGBPCVAC
|
8.2 | IC50 | 2 | — | |
SITLTVJDDVYTEN
|
8.2 | IC50 | 2 | — | |
CCWWRYWEYAHFOL
|
8.2 | IC50 | 2 | — | |
SSKFWKZRFZKTNE
|
8.2 | IC50 | 2 | — | |
GARGJFCAYIKMFS
|
8.1 | IC50 | 2 | — | |
YJAXMKLBTAPZLH
|
8.1 | IC50 | 2 | — | |
UIARLYUEJFELEN
|
8.1 | Kd | 289 | Yes | |
BPZMTSRVPSGZIV
|
8.0 | IC50 | 3 | — | |
JNXWYRLSXQVBBC
|
8.0 | IC50 | 2 | — | |
VNCIJMRFIRKERM
|
8.0 | IC50 | 3 | — | |
HLIYWFVKEYJMNH
|
7.9 | IC50 | 2 | — | |
ZRDGRMBWTYNOHB
|
7.9 | IC50 | 2 | — | |
YDGFHFMRNSUOFT
|
7.8 | IC50 | 2 | — | |
YYPDSPUGDQIDOX
|
7.8 | IC50 | 3 | — | |
UIQXGRWIXZNVST
|
7.7 | IC50 | 2 | — | |
HTZGCLACEOMUOV
|
7.6 | IC50 | 2 | — | |
RDTKDSIRKDXUTE
|
7.6 | IC50 | 2 | — | |
OHOGGIZZDHRWBN
|
7.5 | IC50 | 3 | — | |
OZEUHFQBMMLXLH
|
7.5 | IC50 | 3 | — | |
FOQWDEYRKZAGHG
|
7.5 | IC50 | 2 | — | |
RDNOLDWOMGZBPI
|
7.5 | IC50 | 8 | Yes | |
WKCUMDOOJAZCDE
|
7.5 | IC50 | 4 | — | |
ZFDSWWQGWFRMQV
|
7.5 | IC50 | 2 | — | |
JPOSFPUHBHRUAX
|
7.5 | IC50 | 40 | Yes | |
HKSZLNNOFSGOKW
|
7.4 | IC50 | 49 | Yes | |
MFIHEMURNUGWKL
|
7.4 | IC50 | 2 | — | |
REPJKBLVQPPXEF
|
7.4 | IC50 | 2 | — | |
ODPGGGTTYSGTGO
|
7.4 | Kd | 153 | — | |
AQRJVDRPEZNKRQ
|
7.4 | IC50 | 2 | — | |
CLRVYWUBJBJDOI
|
7.4 | IC50 | 2 | — | |
DKWGAYFHMCUJEN
|
7.3 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
7.3 | Ki | 118 | — | |
QSVAKVTVKQXSBC
|
7.3 | IC50 | 2 | — | |
YDELNSXADYPQGS
|
7.3 | IC50 | 15 | Yes | |
HKSZLNNOFSGOKW
|
7.2 | IC50 | 408 | — | |
JMPYOBZSMKYCFM
|
7.1 | IC50 | 4 | — | |
MPTGZYHKBIOUAJ
|
7.1 | Ki | 2 | — | |
QFHPSDWMERSJDZ
|
7.1 | IC50 | 4 | — | |
WMGRMDGUJMSYTC
|
7.1 | IC50 | 2 | — | |
XTZAKDCUSWPOCM
|
7.1 | IC50 | 2 | — | |
ZBAFXJXHSORURK
|
7.1 | IC50 | 4 | — | |
YMUVNLHJBBMIFJ
|
7.0 | IC50 | 2 | — | |
FQYLJBVSYHZWLT
|
7.0 | Ki | 35 | Yes | |
JZRMBDHPALEPDM
|
7.0 | IC50 | 3 | — | |
KASDTXOUSYBOPY
|
7.0 | IC50 | 3 | — | |
MRDGEZUUEBHTNO
|
7.0 | IC50 | 3 | — | |
QVWIVWPIJUYRRF
|
7.0 | IC50 | 8 | Yes | |
ZTGYDXUZLFXOIX
|
7.0 | IC50 | 2 | — |