Target Details
| UniProt AC | O14920 |
|---|---|
| Gene Symbol | IKBKB |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18397 (IKBKB_SDD) PF12179 (IKKbetaNEMObind) PF00069 (Pkinase) |
Summary
- Multi-target molecules 411
- Clinical molecules 17
- Avg pChEMBL 8.02
KEGG Pathways (60)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- MicroRNAs in cancer
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Type II diabetes mellitus
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (411)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OUEKIUOANBSUEO
|
7.1 | Ki | 2 | — | |
BSPKIJMBEIELMN
|
7.1 | IC50 | 7 | — | |
MYMIPUOCKZMJRL
|
7.1 | Ki | 2 | — | |
RJXLKDFSBJOHBM
|
7.0 | IC50 | 4 | Yes | |
GZNQUYJRMNUIKM
|
7.0 | Ki | 2 | — | |
UTYBUUVNQWMPHL
|
7.0 | IC50 | 2 | — | |
XJLFMRGTLRIXDT
|
7.0 | IC50 | 2 | — | |
YFZKQJYONASWFW
|
7.0 | IC50 | 7 | — | |
ANKQIJATDOANHF
|
7.0 | Ki | 2 | — | |
MQYWUAVOLVOSFD
|
7.0 | IC50 | 7 | — | |
ODPGGGTTYSGTGO
|
7.0 | Kd | 153 | — | |
MNHPQFWACBMBQT
|
6.9 | IC50 | 2 | — | |
DDEHKSKCGIBOPH
|
6.9 | IC50 | 2 | — | |
PPHJGMVOOBKFEI
|
6.9 | IC50 | 2 | — | |
XJVGQDMDOVIHME
|
6.9 | IC50 | 6 | — | |
GXZFDXZCJALHRF
|
6.9 | IC50 | 6 | — | |
FPINDZMLPPFGBN
|
6.8 | Ki | 2 | — | |
IZGQPLWVVNTXJB
|
6.8 | IC50 | 2 | — | |
NVHVDZKSZLWUNH
|
6.8 | IC50 | 5 | — | |
AJFYMCKXLCRURF
|
6.8 | IC50 | 5 | — | |
DCEAJJZHQFOWRL
|
6.8 | IC50 | 3 | — | |
JZRMBDHPALEPDM
|
6.8 | IC50 | 3 | — | |
NMQGPYPYJSEVSC
|
6.8 | IC50 | 4 | Yes | |
BWZCCEYPZOYICS
|
6.8 | IC50 | 2 | — | |
KIMCXIRMMLNCFO
|
6.8 | IC50 | 8 | — | |
NNJUNDLQIUBFIU
|
6.8 | IC50 | 2 | — | |
RJZDECGDCKOHBV
|
6.8 | Ki | 70 | — | |
UISYHKUAFRQWRK
|
6.8 | IC50 | 2 | — | |
BNRXMSGHPVYSDK
|
6.8 | IC50 | 24 | — | |
ICDRBJJBVQGHAV
|
6.8 | Ki | 2 | — | |
WHJZGZLLYCQKOO
|
6.8 | IC50 | 3 | — | |
GIBYRJLRSLPQGP
|
6.7 | IC50 | 6 | — | |
PPTMHEJDLKABRA
|
6.7 | IC50 | 2 | — | |
DCUSCHYHFUKBTL
|
6.7 | Ki | 2 | — | |
JQFFORXNDDEBAU
|
6.7 | IC50 | 2 | — | |
RULRLUFVKXIRNZ
|
6.7 | IC50 | 2 | — | |
YLRZEPPAUZLMKR
|
6.7 | IC50 | 7 | — | |
CHILCFMQWMQVAL
|
6.7 | IC50 | 6 | — | |
HKSZLNNOFSGOKW
|
6.6 | IC50 | 408 | — | |
CLVARCBGXGKOMT
|
6.6 | Ki | 2 | — | |
QTXIZTUQLFYMNF
|
6.6 | Ki | 2 | — | |
XNSRBVPDGAZWDJ
|
6.6 | IC50 | 7 | — | |
PSPFQEBFYXJZEV
|
6.6 | IC50 | 10 | — | |
ARAKMVRBBTWPJZ
|
6.6 | IC50 | 2 | — | |
FMIIOKMEEXTVQD
|
6.6 | IC50 | 2 | — | |
HAFBRQDBRQDCSQ
|
6.6 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
6.6 | Ki | 118 | — | |
IVJPEEHVYKDQEO
|
6.6 | IC50 | 2 | — | |
JLXHKQDBDWGYJH
|
6.6 | IC50 | 2 | — | |
JPOSFPUHBHRUAX
|
6.6 | Ki | 40 | Yes |