Target Details
| UniProt AC | O14920 |
|---|---|
| Gene Symbol | IKBKB |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18397 (IKBKB_SDD) PF12179 (IKKbetaNEMObind) PF00069 (Pkinase) |
Summary
- Multi-target molecules 411
- Clinical molecules 17
- Avg pChEMBL 8.02
KEGG Pathways (60)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- MicroRNAs in cancer
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Type II diabetes mellitus
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (411)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CTEHMRUJZDTSPT
|
7.6 | IC50 | 2 | — | |
NESVCOQUFDGZKO
|
7.6 | IC50 | 2 | — | |
HTZGCLACEOMUOV
|
7.6 | IC50 | 2 | — | |
ILOYIIQDZQBDDS
|
7.6 | IC50 | 2 | — | |
FIQTXYWPQFVIMD
|
7.5 | Ki | 2 | — | |
VKGBHSPPHIPQGF
|
7.5 | IC50 | 2 | — | |
LDGNCLMLMHSOCB
|
7.5 | IC50 | 2 | — | |
NNSYVCGIXIMRBO
|
7.5 | Ki | 2 | — | |
GOMYNFJETMROPO
|
7.5 | Ki | 2 | — | |
SKZBDNWUNUGWAT
|
7.5 | IC50 | 2 | — | |
XFBXVQWOKZPIMH
|
7.5 | Ki | 2 | — | |
ZTBJDQDNHPHYGS
|
7.5 | IC50 | 7 | — | |
GEUVTMHWYJKVCS
|
7.5 | Ki | 2 | — | |
MXCVCAHPICGSHU
|
7.4 | IC50 | 2 | — | |
UFUGWYGOPDUQPL
|
7.4 | Ki | 2 | — | |
IPILWECSKGVOIC
|
7.4 | IC50 | 2 | — | |
KXOHHYYRWKLTPP
|
7.4 | IC50 | 7 | — | |
HNQXYQNMPSACKT
|
7.4 | IC50 | 4 | — | |
JVYHBYVCMJECCB
|
7.4 | IC50 | 2 | — | |
OZEUHFQBMMLXLH
|
7.4 | IC50 | 3 | — | |
REPJKBLVQPPXEF
|
7.4 | IC50 | 2 | — | |
XMLJHUDPEAJQOK
|
7.4 | IC50 | 2 | — | |
ZFDSWWQGWFRMQV
|
7.4 | IC50 | 2 | — | |
YMUVNLHJBBMIFJ
|
7.4 | IC50 | 2 | — | |
AQRJVDRPEZNKRQ
|
7.4 | IC50 | 2 | — | |
MAFLHOXURZCIKH
|
7.4 | IC50 | 2 | — | |
MCGRFOSDZZVTTO
|
7.4 | IC50 | 2 | — | |
OHOGGIZZDHRWBN
|
7.4 | IC50 | 3 | — | |
CLRVYWUBJBJDOI
|
7.4 | IC50 | 2 | — | |
HWIDIXYYYBFSPD
|
7.4 | IC50 | 2 | — | |
VSEFBGXIMFQPOP
|
7.3 | IC50 | 2 | — | |
ZNOLRTPMNMPLHY
|
7.3 | IC50 | 6 | — | |
NDMYTORHXSWZLR
|
7.3 | Ki | 2 | — | |
GKXBHPHFYKGOGD
|
7.3 | Ki | 2 | — | |
IYHHRZBKXXKDDY
|
7.3 | IC50 | 6 | — | |
MRDGEZUUEBHTNO
|
7.3 | IC50 | 3 | — | |
KIHVUPJHESXXLX
|
7.3 | IC50 | 7 | — | |
GEAPVWOLRPIXJU
|
7.2 | IC50 | 2 | — | |
CDNQNPSWFHDZDZ
|
7.2 | IC50 | 2 | — | |
GZGLPBNOIFLLRE
|
7.2 | IC50 | 6 | — | |
RJBNLDIMJDGXNV
|
7.2 | IC50 | 2 | — | |
VAHXNZORWIHLEA
|
7.2 | Ki | 2 | — | |
BZCJVNQGZAKKFZ
|
7.2 | Ki | 2 | — | |
NHHQJBCNYHBUSI
|
7.2 | Kd | 220 | — | |
NDMYTORHXSWZLR
|
7.1 | Ki | 2 | — | |
MFIHEMURNUGWKL
|
7.1 | IC50 | 2 | — | |
DKWGAYFHMCUJEN
|
7.1 | IC50 | 2 | — | |
FQYLJBVSYHZWLT
|
7.1 | Ki | 35 | Yes | |
RDNOLDWOMGZBPI
|
7.1 | IC50 | 8 | Yes | |
XTZAKDCUSWPOCM
|
7.1 | IC50 | 2 | — |