Target Details
| UniProt AC | O14920 |
|---|---|
| Gene Symbol | IKBKB |
| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18397 (IKBKB_SDD) PF12179 (IKKbetaNEMObind) PF00069 (Pkinase) |
Summary
- Multi-target molecules 411
- Clinical molecules 17
- Avg pChEMBL 8.02
KEGG Pathways (60)
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Antifolate resistance
- Apoptosis
- B cell receptor signaling pathway
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Coronavirus disease - COVID-19
- Cytosolic DNA-sensing pathway
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Fluid shear stress and atherosclerosis
- FoxO signaling pathway
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- MicroRNAs in cancer
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Prostate cancer
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Type II diabetes mellitus
- Yersinia infection
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (411)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UVFSTSPRWWDUAW
|
7.9 | IC50 | 5 | — | |
UIARLYUEJFELEN
|
7.9 | Kd | 289 | Yes | |
KQGQDDJOYKZFPV
|
7.9 | IC50 | 8 | — | |
HLIYWFVKEYJMNH
|
7.9 | IC50 | 2 | — | |
YJAXMKLBTAPZLH
|
7.9 | IC50 | 2 | — | |
PSVUSJKZJQMCSP
|
7.9 | IC50 | 2 | — | |
WONYOHLOECXBDY
|
7.9 | IC50 | 2 | — | |
NNSYVCGIXIMRBO
|
7.9 | Ki | 2 | — | |
CGFXZRMWTJZUIE
|
7.9 | Ki | 2 | — | |
PBEDKMOIZRXVCC
|
7.9 | Ki | 2 | — | |
ILOYIIQDZQBDDS
|
7.8 | IC50 | 2 | — | |
ONEVJHJFIVPBQA
|
7.8 | IC50 | 5 | — | |
SRRNUFQCQFVAPF
|
7.8 | IC50 | 3 | — | |
YDGFHFMRNSUOFT
|
7.8 | IC50 | 2 | — | |
GWFPIZIGIZUHPF
|
7.8 | Ki | 2 | — | |
BYMRVDVGQVMXFP
|
7.8 | IC50 | 2 | — | |
CHZVFENZCVWBMI
|
7.8 | IC50 | 2 | — | |
FOQWDEYRKZAGHG
|
7.8 | IC50 | 2 | — | |
PLUJEADAMOIDHN
|
7.8 | IC50 | 6 | — | |
QSVAKVTVKQXSBC
|
7.8 | IC50 | 2 | — | |
TXBCKCGOGPLPMZ
|
7.8 | IC50 | 8 | — | |
UWDMHLZUTCJHIF
|
7.8 | IC50 | 2 | — | |
WFIYKEJGYKFLJS
|
7.8 | Ki | 2 | — | |
NXAKTRYQXPJCEF
|
7.8 | Ki | 2 | — | |
SMBHSFZUMVAXOR
|
7.8 | Ki | 2 | — | |
VBERPYKUAWCROV
|
7.8 | IC50 | 5 | — | |
DAIJCSSJLOPSOK
|
7.8 | Ki | 2 | — | |
MURRHZDIBOUBHB
|
7.8 | IC50 | 7 | — | |
GKXBHPHFYKGOGD
|
7.7 | Ki | 2 | — | |
SZBKUUYQNSJGMR
|
7.7 | IC50 | 2 | — | |
UMGOIQFASVFXBU
|
7.7 | IC50 | 2 | — | |
UOQMKZIYNRHZEF
|
7.7 | IC50 | 2 | — | |
RXXFAHMIZHWGQM
|
7.7 | Ki | 2 | — | |
MTUNOSRERUFMFB
|
7.7 | IC50 | 2 | — | |
SAYGKHKXGCPTLX
|
7.7 | IC50 | 4 | Yes | |
UOVILLRJCVEGLB
|
7.7 | IC50 | 2 | — | |
HDJJCDBHJXIVLV
|
7.7 | Ki | 2 | — | |
FNMOTKZHZAEQQF
|
7.7 | IC50 | 2 | — | |
NFGNAZKUHXHPNH
|
7.7 | IC50 | 2 | — | |
NZANNALXDKRTAW
|
7.7 | IC50 | 2 | — | |
SXUNZFYJEHXSOJ
|
7.7 | IC50 | 3 | — | |
VJODYKRXQHPRCX
|
7.7 | IC50 | 2 | — | |
ZRDGRMBWTYNOHB
|
7.7 | IC50 | 2 | — | |
ZTGYDXUZLFXOIX
|
7.7 | IC50 | 2 | — | |
IVIMPRXKUJSSRR
|
7.7 | Ki | 2 | — | |
LCGRALYGJXIQKN
|
7.7 | IC50 | 2 | — | |
MEXOVCGPGSMZQQ
|
7.7 | IC50 | 2 | — | |
AAFMUTYTWRBOGE
|
7.7 | IC50 | 2 | — | |
UIQXGRWIXZNVST
|
7.7 | IC50 | 2 | — | |
ICDRBJJBVQGHAV
|
7.7 | Ki | 2 | — |