Target Details
| UniProt AC | O14733 |
|---|---|
| Gene Symbol | MAP2K7 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 7 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 15
- Clinical molecules 4
- Avg pChEMBL 6.64
KEGG Pathways (25)
- Alcoholic liver disease
- Alzheimer disease
- Chemical carcinogenesis - reactive oxygen species
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- GnRH signaling pathway
- Hepatitis B
- Human immunodeficiency virus 1 infection
- Huntington disease
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Osteoclast differentiation
- Pathways of neurodegeneration - multiple diseases
- Protein processing in endoplasmic reticulum
- Relaxin signaling pathway
- Salmonella infection
- T cell receptor signaling pathway
- TNF signaling pathway
- Tight junction
- Toll-like receptor signaling pathway
- Yersinia infection
Active Molecules (15)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ODPGGGTTYSGTGO
|
7.6 | Kd | 153 | — | |
XXFDMGXYEIKFNZ
|
7.5 | IC50 | 2 | — | |
UIARLYUEJFELEN
|
7.1 | Kd | 289 | Yes | |
CPIXJBLUTUTAEN
|
7.0 | IC50 | 2 | — | |
OMZCMEYTWSXEPZ
|
7.0 | Kd | 43 | Yes | |
HKSZLNNOFSGOKW
|
6.9 | IC50 | 408 | — | |
OSAWFUCUZJNEID
|
6.7 | IC50 | 20 | — | |
NXSJMRCTGYTSTK
|
6.5 | Kd | 200 | — | |
NEQZWEXWOFPKOT
|
6.5 | IC50 | 9 | — | |
JWNPDZNEKVCWMY
|
6.3 | Kd | 57 | Yes | |
PKPLGKVAJMCSQQ
|
6.3 | IC50 | 2 | — | |
ORHOFZHZKBMJDI
|
6.1 | IC50 | 2 | — | |
JCJAEEODSKNKTC
|
6.1 | IC50 | 6 | Yes | |
RNVLUCHCKZGJKL
|
6.0 | IC50 | 2 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — |