Target Details
| UniProt AC | O14727 |
|---|---|
| Gene Symbol | APAF1 |
| Protein Name | Apoptotic protease-activating factor 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF17908 (APAF1_C) PF00619 (CARD) PF00931 (NB-ARC) PF00400 (WD40) PF21296 (WHD_APAF1) |
Summary
- Multi-target molecules 5
- Clinical molecules 0
- Avg pChEMBL 6.97
KEGG Pathways (21)
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Apoptosis - multiple species
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Huntington disease
- Influenza A
- Legionellosis
- Lipid and atherosclerosis
- Measles
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Platinum drug resistance
- Prion disease
- Small cell lung cancer
- Tuberculosis
- p53 signaling pathway
Active Molecules (5)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CPXHNWKHOFNPDO
|
7.4 | IC50 | 8 | — | |
BMHKZVDHCKLDME
|
7.2 | IC50 | 3 | — | |
HDXJYJIPXWVRSM
|
7.1 | IC50 | 3 | — | |
SSWVPYMSHHEYAB
|
6.7 | IC50 | 4 | — | |
RHYVGCKRBKDRDX
|
6.3 | IC50 | 2 | — |