Target Details
| UniProt AC | O00459 |
|---|---|
| Gene Symbol | PIK3R2 |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16454 (PI3K_P85_iSH2) PF00620 (RhoGAP) PF00017 (SH2) |
Summary
- Multi-target molecules 485
- Clinical molecules 2
- Avg pChEMBL 6.86
KEGG Pathways (106)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (485)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SWVKCQPGFPNXKD
|
6.2 | IC50 | 8 | — | |
VJKOJLHWXVHBEO
|
6.2 | IC50 | 8 | — | |
BIIDDVUADIUYBJ
|
6.2 | IC50 | 3 | — | |
CJHYSTAAWQXULJ
|
6.2 | IC50 | 3 | — | |
LLFDYWNVHVGBTE
|
6.2 | IC50 | 8 | — | |
NLUPPCTVKHDVIQ
|
6.2 | IC50 | 5 | — | |
AMJGHFJJBCBWSW
|
6.2 | IC50 | 8 | — | |
CJPQLVKEJCSHCZ
|
6.2 | IC50 | 8 | — | |
FNRBEWROUCTVGO
|
6.2 | IC50 | 2 | — | |
FZTRXYHXXBNKJS
|
6.2 | IC50 | 3 | — | |
RAUVXDWZUJNWQV
|
6.2 | IC50 | 8 | — | |
VSMGPYBHOWPQLX
|
6.2 | IC50 | 8 | — | |
WNZLZUPJEKQNRS
|
6.2 | IC50 | 8 | — | |
DXVNZJPLZVVVKZ
|
6.2 | IC50 | 8 | — | |
JZKZXNIZTRPDEJ
|
6.2 | IC50 | 8 | — | |
KRMUQSJATKUTQW
|
6.2 | IC50 | 8 | — | |
PEQASWCNDKRNPZ
|
6.2 | IC50 | 8 | — | |
BRGMYJHLZVBEGE
|
6.2 | IC50 | 8 | — | |
CHYGZQVJMLTYPP
|
6.2 | IC50 | 8 | — | |
NQGQCKYICODPRT
|
6.2 | IC50 | 8 | — | |
SWHDQTHOFGUWTP
|
6.2 | IC50 | 8 | — | |
WKHVREDXOZYDKG
|
6.2 | IC50 | 8 | — | |
YGYMLYFXPLWCSP
|
6.2 | IC50 | 8 | — | |
AHWHGALWRKOGIW
|
6.2 | IC50 | 8 | — | |
JBEDJEOXQRSVHA
|
6.2 | IC50 | 8 | — | |
PGOGWPYCIZVYBQ
|
6.2 | IC50 | 8 | — | |
PUOJAIRQIFIHLD
|
6.2 | IC50 | 8 | — | |
AJNVYCYEQWOCQG
|
6.2 | IC50 | 8 | — | |
PRANHWURGNZBDG
|
6.2 | IC50 | 8 | — | |
ALNSNMBSENGUSM
|
6.1 | IC50 | 8 | — | |
QHJCZEWWMRECJB
|
6.1 | IC50 | 2 | — | |
CZQHHVNHHHRRDU
|
6.1 | IC50 | 12 | Yes | |
OBWJIWMQAUQEMB
|
6.1 | IC50 | 8 | — | |
VCDIOTUYORTDHC
|
6.1 | IC50 | 2 | — | |
VWNUIZMUGGBKPQ
|
6.1 | IC50 | 8 | — | |
WXQSAROWLFBICE
|
6.1 | IC50 | 8 | — | |
XFROLARWNLOEQS
|
6.1 | IC50 | 8 | — | |
AQRDGDLKJXPNBL
|
6.1 | IC50 | 2 | — | |
BCNGCKQHALFUMO
|
6.1 | IC50 | 2 | — | |
CTIGGQZHWXNPRX
|
6.1 | IC50 | 2 | — | |
IFNOMKJYHWTMCH
|
6.1 | IC50 | 2 | — | |
IGTBYCFFPQILQK
|
6.1 | IC50 | 2 | — | |
JFOUTONBSIXQAW
|
6.1 | IC50 | 2 | — | |
LAXCPCHPIFTFEJ
|
6.1 | IC50 | 8 | — | |
RJPQDGBWPPNUQX
|
6.1 | IC50 | 8 | — | |
VNMGYZXVKMIRFY
|
6.1 | IC50 | 4 | — | |
YWGQHTIWEBSYGE
|
6.1 | IC50 | 3 | — | |
KANIKZLNGVDVBI
|
6.1 | IC50 | 8 | — | |
MBCLTTATBWHRGR
|
6.1 | IC50 | 8 | — | |
WJCYHWGNDVBBPJ
|
6.1 | IC50 | 8 | — |