Target Details
| UniProt AC | O00459 |
|---|---|
| Gene Symbol | PIK3R2 |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16454 (PI3K_P85_iSH2) PF00620 (RhoGAP) PF00017 (SH2) |
Summary
- Multi-target molecules 485
- Clinical molecules 2
- Avg pChEMBL 6.86
KEGG Pathways (106)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (485)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VBARFYIZOQPRIU
|
6.9 | IC50 | 8 | — | |
GLLFQTCFJDJTEY
|
6.9 | IC50 | 8 | — | |
WPSIRTUKJQGAMQ
|
6.9 | IC50 | 3 | — | |
ZWEJBXXYQYTACR
|
6.9 | Ki | 6 | — | |
FDEAQYIYQUZQAJ
|
6.9 | IC50 | 8 | — | |
FVCYICGIUXQQRS
|
6.9 | IC50 | 8 | — | |
CRENPEXXTIJKAA
|
6.9 | IC50 | 8 | — | |
NGEJUHOFRLFZDS
|
6.8 | IC50 | 2 | — | |
VCRLQSFXJXKZCT
|
6.8 | IC50 | 2 | — | |
VITSWBMXSGIZBK
|
6.8 | IC50 | 8 | — | |
ZUALWMVUCJAHIZ
|
6.8 | IC50 | 2 | — | |
UBWTUXFRFOVNSZ
|
6.8 | IC50 | 8 | — | |
URZITQGEWBAINN
|
6.8 | IC50 | 8 | — | |
CLIQXBIMBUOULG
|
6.8 | IC50 | 2 | — | |
DKTVIRHTLKBNCA
|
6.8 | IC50 | 2 | — | |
QFZUHGQPUAICER
|
6.8 | IC50 | 2 | — | |
RZMCOKXGGNPJRT
|
6.8 | IC50 | 3 | — | |
DVJHHRDBSCMRFO
|
6.8 | IC50 | 8 | — | |
GCMPYYJJMWUTQX
|
6.8 | IC50 | 8 | — | |
TWSFAEOUABXTKC
|
6.8 | IC50 | 8 | — | |
RCDKXUXYPKPWOL
|
6.8 | IC50 | 8 | — | |
ZNOQCQOSJQSWLD
|
6.8 | IC50 | 3 | — | |
ZNOQCQOSJQSWLD
|
6.8 | IC50 | 3 | — | |
OQNSHGSWBWLCGD
|
6.8 | IC50 | 8 | — | |
NUBPXPBMWBORQH
|
6.8 | IC50 | 8 | — | |
QINAYZWLPHRNRP
|
6.8 | IC50 | 8 | — | |
XTJYQRUVPWZZMO
|
6.8 | IC50 | 8 | — | |
NFVBVBZCCSWOGV
|
6.8 | IC50 | 8 | — | |
QIIACSBLOYITSG
|
6.8 | IC50 | 8 | — | |
DEQCFSACIVEXND
|
6.8 | IC50 | 6 | — | |
LTZAFUIAXJDTFA
|
6.8 | IC50 | 2 | — | |
DKBIFPXBCXSLNM
|
6.8 | IC50 | 8 | — | |
DTNRKAREUFEJOT
|
6.8 | IC50 | 8 | — | |
CMXRXQRAMDWNNS
|
6.7 | IC50 | 2 | — | |
KXUYUETUZFPOQS
|
6.7 | IC50 | 8 | — | |
OOGFHRAURPOHAA
|
6.7 | IC50 | 8 | — | |
KPFIPJMXDOSFKZ
|
6.7 | IC50 | 8 | — | |
HYFOWZDHZOPTAI
|
6.7 | IC50 | 8 | — | |
KTHRNFFLSRMPKO
|
6.7 | IC50 | 2 | — | |
MDBPGMMGPFYUIX
|
6.7 | IC50 | 8 | — | |
NVYSXOUUPYKYTR
|
6.7 | IC50 | 3 | — | |
JXIVPCDJNLIENJ
|
6.7 | IC50 | 8 | — | |
DMLMQDOHTGPLQS
|
6.7 | IC50 | 8 | — | |
IESFUCNDFAMVCD
|
6.7 | IC50 | 2 | — | |
SYVHOZRIBZQVSX
|
6.7 | IC50 | 8 | — | |
VUTWTOWSCDWESM
|
6.7 | IC50 | 8 | — | |
MTZPRXJYCMSNJU
|
6.7 | IC50 | 2 | — | |
BYTKNUOMWLJVNQ
|
6.7 | IC50 | 10 | — | |
SUENWRGZWCPLSE
|
6.7 | IC50 | 8 | — | |
ALTWEBDMLOHYHS
|
6.7 | IC50 | 8 | — |