Target Details
| UniProt AC | O00459 |
|---|---|
| Gene Symbol | PIK3R2 |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16454 (PI3K_P85_iSH2) PF00620 (RhoGAP) PF00017 (SH2) |
Summary
- Multi-target molecules 485
- Clinical molecules 2
- Avg pChEMBL 6.86
KEGG Pathways (106)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (485)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HHWJHMRRVGPBRZ
|
6.1 | IC50 | 2 | — | |
LLSPYQXCBDPCKL
|
6.1 | IC50 | 8 | — | |
MIFBYDPTRPDGOS
|
6.1 | IC50 | 8 | — | |
OEIOLSPGSQHWDG
|
6.1 | Ki | 6 | — | |
GWZVMSSDIBHICV
|
6.1 | IC50 | 8 | — | |
HTFVOKCSBZNVCM
|
6.1 | IC50 | 8 | — | |
NORWTLLCOTYPQA
|
6.1 | IC50 | 8 | — | |
NUVNLRITBKISJS
|
6.1 | IC50 | 8 | — | |
UKYZNGMYDHPKCT
|
6.1 | IC50 | 8 | — | |
ZKWDLVOBNAKZMP
|
6.1 | IC50 | 2 | — | |
MEDJQGQNXIYESM
|
6.1 | IC50 | 8 | — | |
XQTHYNKOCLMRDN
|
6.1 | IC50 | 8 | — | |
ZQMRWZWYYAEHCM
|
6.1 | IC50 | 8 | — | |
NNJFATAWXWTKJW
|
6.0 | IC50 | 8 | — | |
XMIXKIYGSBKJHW
|
6.0 | IC50 | 8 | — | |
BZTIAAOQYKUYMP
|
6.0 | IC50 | 8 | — | |
CDCYZIADQZZXOR
|
6.0 | IC50 | 8 | — | |
DLBMZAAMUILROS
|
6.0 | IC50 | 8 | — | |
DPXYTFRWYCEDNN
|
6.0 | IC50 | 8 | — | |
GRNHQFWGZJVSRA
|
6.0 | IC50 | 8 | — | |
JYIFPSUOBKZKQB
|
6.0 | IC50 | 2 | — | |
NLTSUUCKGVRGEB
|
6.0 | IC50 | 8 | — | |
OGYFPXUBCVSJHC
|
6.0 | IC50 | 2 | — | |
TWYYRCNMQXRTJG
|
6.0 | IC50 | 8 | — | |
XLVLZQZUUOKWBV
|
6.0 | IC50 | 8 | — | |
AGHMOGGRPAZCJV
|
6.0 | IC50 | 8 | — | |
CVCJRLFLUNVQFB
|
6.0 | IC50 | 3 | — | |
NLPLFNLMHHBEKR
|
6.0 | IC50 | 8 | — | |
RZZKNWAYYKUPNA
|
6.0 | IC50 | 8 | — | |
BGDMDSJUNDOCFL
|
6.0 | IC50 | 2 | — | |
FJLPTFADSJAOAV
|
6.0 | IC50 | 8 | — | |
HCJSEKPCERDAAK
|
6.0 | IC50 | 2 | — | |
LSMFRSSROQIZIC
|
6.0 | IC50 | 8 | — | |
LVWLARJYGFSMKW
|
6.0 | IC50 | 2 | — | |
YCDRKRFDMPJHDQ
|
6.0 | IC50 | 8 | — |