Target Details
| UniProt AC | O00459 |
|---|---|
| Gene Symbol | PIK3R2 |
| Protein Name | Phosphatidylinositol 3-kinase regulatory subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF16454 (PI3K_P85_iSH2) PF00620 (RhoGAP) PF00017 (SH2) |
Summary
- Multi-target molecules 485
- Clinical molecules 2
- Avg pChEMBL 6.86
KEGG Pathways (106)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (485)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SJZBTEVPBCUZGB
|
9.0 | IC50 | 3 | — | |
ZQTOIAUDKJDPEL
|
9.0 | IC50 | 3 | — | |
GDZNVPWDBYHIJL
|
8.5 | IC50 | 6 | — | |
SBVBUGSOYHJGGD
|
8.5 | IC50 | 5 | — | |
CMYSTKGRHNPEGZ
|
8.4 | IC50 | 3 | — | |
NBLUFAUIHOHBMV
|
8.4 | IC50 | 3 | — | |
OFMDSJCSRJNWNL
|
8.4 | IC50 | 3 | — | |
PQANOGPKBULQEK
|
8.4 | IC50 | 3 | — | |
PXXWCCCMEWRBCG
|
8.4 | IC50 | 3 | — | |
XEFPRVONPORJSI
|
8.4 | IC50 | 5 | — | |
VNEYUEOUGLBEAK
|
8.4 | IC50 | 2 | — | |
HXPSIAFBTGCSJP
|
8.3 | IC50 | 2 | — | |
MASYQGOSXMDVNJ
|
8.3 | IC50 | 5 | — | |
MDDXMEMWUQXULT
|
8.3 | IC50 | 3 | — | |
OCYOKXUKMYJXOI
|
8.3 | IC50 | 3 | — | |
FYGDHTMAQTVJIR
|
8.2 | IC50 | 8 | — | |
HDLCAAPRCRFECO
|
8.2 | IC50 | 6 | — | |
YUTGMYOFQLLTIR
|
8.2 | IC50 | 2 | — | |
BJNCOVPPPKXBBA
|
8.2 | IC50 | 8 | — | |
DNWXCIODCKXDCW
|
8.2 | IC50 | 2 | — | |
GWHTZAJWFQFBJO
|
8.2 | IC50 | 2 | — | |
QCSBWICWLKTERT
|
8.2 | IC50 | 5 | — | |
VLTAYJGDBHDHFT
|
8.2 | IC50 | 3 | — | |
DHBOKNWOMUOAJH
|
8.1 | IC50 | 2 | — | |
QAXIFNVRGZPQFY
|
8.1 | IC50 | 3 | — | |
WDKCXLAMBYVFKX
|
8.1 | IC50 | 2 | — | |
CKESRBMHGGWAAT
|
8.1 | IC50 | 3 | — | |
KGAIGCKEYVLSKU
|
8.1 | IC50 | 3 | — | |
LJECJJAGVWBQBT
|
8.1 | IC50 | 3 | — | |
ARNQAFCNBDJMDL
|
8.0 | IC50 | 3 | — | |
QUDFJWGWCAJQGK
|
8.0 | IC50 | 5 | — | |
GPBJZHQBTXHZRQ
|
8.0 | IC50 | 5 | — | |
NFMJPNIMDSAFQE
|
8.0 | IC50 | 6 | — | |
NLZNQTSAEGRBEQ
|
8.0 | IC50 | 8 | — | |
LRNJBEMBOKBVLE
|
7.9 | IC50 | 3 | — | |
MRWHKPAFXPUCAH
|
7.9 | IC50 | 3 | — | |
UKNFKMCRDXQKMX
|
7.9 | IC50 | 5 | — | |
CVJYZNKVAFBTDT
|
7.9 | IC50 | 8 | — | |
FGJSGEOFFFKFLV
|
7.9 | IC50 | 8 | — | |
FGSUYFKYDAGEPH
|
7.9 | IC50 | 3 | — | |
NORWTLLCOTYPQA
|
7.9 | IC50 | 8 | — | |
AVPAAQMVQVGYGP
|
7.8 | IC50 | 8 | — | |
FUMQATBGDGLOKH
|
7.8 | IC50 | 8 | — | |
JTCAOANACJRIAJ
|
7.8 | IC50 | 2 | — | |
MGWPOIMLIUPKNZ
|
7.8 | IC50 | 8 | — | |
QXVMJULCQQDHKX
|
7.8 | IC50 | 8 | — | |
YXEXLSYLPLWISV
|
7.8 | IC50 | 2 | — | |
GALWNKLIQPVNFO
|
7.8 | IC50 | 8 | — | |
WJNLASRFJUMLIF
|
7.8 | IC50 | 8 | — | |
WJNLASRFJUMLIF
|
7.8 | IC50 | 8 | — |