Target Details
| UniProt AC | O00206 |
|---|---|
| Gene Symbol | TLR4 |
| Protein Name | Toll-like receptor 4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF12799 (LRR_4) PF13516 (LRR_6) PF13855 (LRR_8) PF01582 (TIR) |
Summary
- Multi-target molecules 9
- Clinical molecules 0
- Avg pChEMBL 7.02
KEGG Pathways (31)
- Alcoholic liver disease
- Amoebiasis
- Chagas disease
- Coronavirus disease - COVID-19
- HIF-1 signaling pathway
- Hepatitis B
- Human immunodeficiency virus 1 infection
- Inflammatory bowel disease
- Influenza A
- Legionellosis
- Leishmaniasis
- Lipid and atherosclerosis
- Malaria
- Measles
- NF-kappa B signaling pathway
- NOD-like receptor signaling pathway
- Necroptosis
- Neutrophil extracellular trap formation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathogenic Escherichia coli infection
- Pertussis
- Phagosome
- Proteoglycans in cancer
- Rheumatoid arthritis
- Salmonella infection
- Shigellosis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Yersinia infection
Associated Diseases (1)
Active Molecules (9)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NXHCAFUXBNDVPQ
|
9.0 | Kd | 2 | — | |
DYXURAPYHRIZKS
|
8.8 | Kd | 2 | — | |
BNJHODUFTHNSSD
|
6.7 | Kd | 2 | — | |
BAXJHONNMJACGU
|
6.7 | IC50 | 3 | — | |
HXNXQEPVMMJRTG
|
6.6 | IC50 | 4 | — | |
QDMWTNUZGRPLNU
|
6.5 | IC50 | 2 | — | |
IOVUIBJPWGTRGS
|
6.3 | IC50 | 2 | — | |
DVZNLDWGORHPAZ
|
6.2 | Kd | 2 | — | |
BSMMDWFKXKVYMQ
|
6.2 | IC50 | 3 | — |