Target Details
UniProt ACA3EZI9
Gene SymbolNS3
Protein NameGenome polyprotein
OrganismHepacivirus hominis
Entry Name
Organism Category Pathogen
Pfam Domains PF07652 (Flavi_DEAD) PF22027 (NS3_helicase_C) PF02907 (Peptidase_S29)
UniProt
Summary
  • Multi-target molecules 670
  • Clinical molecules 0
  • Avg pChEMBL 7.83
Top Co-occurrence Targets
  • NS4A 647 shared
  • 210 shared
  • NS3/4A 205 shared
  • 49 shared
  • 30 shared
  • 29 shared
  • ELANE 13 shared
  • 10 shared
  • CTRC 9 shared
  • 7 shared
Active Molecules (670)
InChIKey pChEMBL Type Targets Clinical
FEPRTNMWSXJNRG 7.6 Ki 2 —
GGMZZIRGFVVFAZ 7.6 Ki 3 —
IRCXUDKSJKTACV 7.6 Ki 2 —
ORROVABYFNDCDM 7.6 Ki 2 —
KHJUFJPLFNKMMO 7.5 IC50 4 —
LTOLYTAOZVUFID 7.5 Ki 2 —
MTWFVSKQCZUCRY 7.5 IC50 3 —
PPLIHRDWIUFUOR 7.5 IC50 4 —
SFKSPKKZUGZHGG 7.5 IC50 4 —
VFFWWNSXYHEQFM 7.5 IC50 4 —
KEUPOUHQSYGYMO 7.5 IC50 2 —
SBCAPAYCNCQYKP 7.5 Ki 2 —
GTWVHISOZCHIMV 7.5 Ki 2 —
AXCREUIWTQWRAS 7.5 IC50 2 —
GGMZZIRGFVVFAZ 7.5 Ki 3 —
OLROIDLEYZUMPK 7.5 IC50 2 —
JLEBKBWONVMYGK 7.5 Ki 2 —
OCMKQVVADOGRPC 7.5 IC50 2 —
GHDPNYZUGAGWJK 7.5 IC50 4 —
KEYZYISKCGSJQI 7.5 IC50 4 —
LXTJVTZCNTYRMW 7.5 IC50 4 —
NAEFTBYPSLMAJV 7.5 IC50 4 —
PLIULJKRSYAXFS 7.5 IC50 2 —
QLSVUCOWXZXLOJ 7.5 IC50 4 —
AWCLTDQQVULZEM 7.4 Ki 2 —
IYYDCFFQTJJOBE 7.4 Ki 2 —
FKGFJFPYHIMVIW 7.4 Ki 2 —
FNJOFQOOHOPNIY 7.4 Ki 3 —
FOCDZTJNLGVNKR 7.4 IC50 2 —
UZMOHPHTITVOKZ 7.4 Ki 2 —
AFUUAGFYLISPHF 7.4 Ki 2 —
KOEJRJBVPQBUHW 7.4 Ki 2 —
MXKUJVFSHRQBEK 7.4 Ki 2 —
OJOOKWRLZOVJGU 7.4 Ki 2 —
OTLBNHZTXGDECC 7.4 Ki 2 —
AQILAUSZMZFFOH 7.4 IC50 4 —
AWQPGSZGZVXQPF 7.4 Ki 3 —
BBAWEDCPNXPBQM 7.4 Ki 3 —
HTJVQVQMSSADLX 7.4 Ki 2 —
LUULFVMVNHPTMD 7.4 IC50 4 —
LWFUGISMHDAPGJ 7.4 IC50 2 —
PPNHBWGLEUAQKU 7.4 Ki 3 —
RKSGIDSCASKYQC 7.4 IC50 4 —
SVIJSFDDCORCGI 7.4 IC50 4 —
TYWGULJNBINZSA 7.4 Ki 2 —
UJAUCRPOZPWCGV 7.4 Ki 3 —
VMGAVHOARRCARD 7.4 IC50 4 —
XCUYYOPASQHWDC 7.4 IC50 2 —
YAFHDFSMUJSRRC 7.4 IC50 4 —
YVMYGONGSKJQTC 7.4 Ki 2 —
2D structure