Target Details
UniProt ACA3EZI9
Gene SymbolNS3
Protein NameGenome polyprotein
OrganismHepacivirus hominis
Entry Name
Organism Category Pathogen
Pfam Domains PF07652 (Flavi_DEAD) PF22027 (NS3_helicase_C) PF02907 (Peptidase_S29)
UniProt
Summary
  • Multi-target molecules 670
  • Clinical molecules 0
  • Avg pChEMBL 7.83
Top Co-occurrence Targets
  • NS4A 647 shared
  • 210 shared
  • NS3/4A 205 shared
  • 49 shared
  • 30 shared
  • 29 shared
  • ELANE 13 shared
  • 10 shared
  • CTRC 9 shared
  • 7 shared
Active Molecules (670)
InChIKey pChEMBL Type Targets Clinical
KUANZLVILBVHBP 6.4 Ki 3 —
SLYQXZVIAACVML 6.4 Ki 2 —
SSGASICGZBSISG 6.4 Ki 2 —
VZXZQIBVXSJQPK 6.4 IC50 3 —
DNDWAIYZEKSILT 6.4 Ki 3 —
BKFUQKRRUFYLMR 6.4 Ki 2 —
DCVKURQOVGDNBK 6.4 Ki 2 —
HTUQPKQGKVEYJP 6.4 IC50 4 —
NUTHSVHYGJKNQX 6.4 Ki 2 —
PNZPPAFNQZUOHS 6.4 Ki 2 —
RNFSHHKIOKRDGR 6.4 IC50 4 —
PMFIMEQVXBHDGJ 6.4 Ki 2 —
FSZCRDFBHYDYEK 6.4 IC50 2 —
VTYFSGSSYMKKDK 6.4 IC50 2 —
AMZZGYSKKBGEAC 6.3 Ki 2 —
AMZZGYSKKBGEAC 6.3 Ki 2 —
DBUUNQACFOZVQH 6.3 Ki 2 —
IVXYYGOHTXDSPQ 6.3 IC50 4 —
IZZDLZKROMAHAV 6.3 IC50 3 —
UQQBDSFNEOSSDH 6.3 Ki 2 —
GZJYZYJQMCNEBL 6.3 Ki 2 —
VNHWCJGVVCSWFF 6.3 IC50 2 —
CBYKXMCQCUOUOF 6.3 Ki 2 —
WABPWGDKPXKISU 6.3 Ki 3 —
FHTWQZRLMPTMOG 6.3 Ki 2 —
KZHDFEYBWTZJGE 6.3 Ki 2 —
KPIPTNOTMDCQDS 6.3 Ki 2 —
LLEUUNMVDOWADP 6.3 Ki 2 —
SFYGZRKQNXBACR 6.3 IC50 4 —
VPHHRKBHKCXJIE 6.3 Ki 2 —
UABMAUQOFZTIIT 6.3 IC50 3 —
SWJQTCTXGIEKDV 6.3 IC50 3 —
CVOFRTRGRUZDMM 6.3 Ki 2 —
HEPRFYCVWWRMAE 6.3 Ki 2 —
BJHYKAIRMZXQJV 6.2 Ki 3 —
FOBANMWDMXKVPX 6.2 Ki 2 —
JXDNUMOTWHZSCB 6.2 Ki 2 —
JXDNUMOTWHZSCB 6.2 Ki 2 —
LNZBSLLYMIIWLE 6.2 Ki 2 —
NTTQHPYEMYJKMD 6.2 Ki 2 —
BALUVGRISHMGIH 6.2 Ki 3 —
DAVSKZZMNSDJOX 6.2 IC50 4 —
PPNHBWGLEUAQKU 6.2 Ki 2 —
QCEJIUAKOBMHJA 6.2 IC50 3 —
SPUIUCLSOFCTHA 6.2 Ki 2 —
SMJTYLAXVKJYOO 6.2 Ki 2 —
XQZCRVGQPRCJCH 6.2 Ki 3 —
BMZCNNDNFOPBLI 6.2 IC50 2 —
HCCZVIPVSOHWHY 6.2 Ki 3 —
AMUHVSMQHTXDEN 6.2 IC50 3 —
2D structure