Target Details
UniProt ACA3EZI9
Gene SymbolNS3
Protein NameGenome polyprotein
OrganismHepacivirus hominis
Entry Name
Organism Category Pathogen
Pfam Domains PF07652 (Flavi_DEAD) PF22027 (NS3_helicase_C) PF02907 (Peptidase_S29)
UniProt
Summary
  • Multi-target molecules 670
  • Clinical molecules 0
  • Avg pChEMBL 7.83
Top Co-occurrence Targets
  • NS4A 647 shared
  • 210 shared
  • NS3/4A 205 shared
  • 49 shared
  • 30 shared
  • 29 shared
  • ELANE 13 shared
  • 10 shared
  • CTRC 9 shared
  • 7 shared
Active Molecules (670)
InChIKey pChEMBL Type Targets Clinical
UYVPXANKULGARL 6.8 Ki 2 —
YSXPOESBGXLPNG 6.8 IC50 2 —
JZMFEPHAYKDGBI 6.7 IC50 2 —
MDZUSCMSYNKTDC 6.7 Ki 2 —
HGTFAIYZZVFMNW 6.7 Ki 2 —
NEJNEOLVTCBNDV 6.7 Ki 2 —
NYVHQORNXOFOPS 6.7 Ki 3 —
PLUSLPDTPSRLBI 6.7 Ki 2 —
LONFZEHXXQEUFG 6.7 Ki 2 —
PEXFKSJDXSBOLP 6.7 Ki 2 —
WBKABXYVMIMBTM 6.7 Ki 2 —
LJWMMWDVXSIMLZ 6.7 Ki 2 —
NYYPPZVRQXLOCV 6.7 Ki 2 —
RBSBNDWTINCGLA 6.7 IC50 2 —
ZDIHAXYHCDOFKU 6.7 Ki 2 —
INGQMIUTDCSMHJ 6.7 IC50 2 —
KSJDADSEXQOUIF 6.7 Ki 3 —
OFCKEZCPNOZAFK 6.7 Ki 2 —
UOUIQOBHGHJVGY 6.7 IC50 2 —
XWQBVLITARLWBM 6.7 Ki 2 —
YOYIMORGSPRZPF 6.7 Ki 3 —
XIEUBHAWLRIJFQ 6.7 IC50 2 —
HRTYEQDANOILAY 6.6 Ki 2 —
MTSMEDVBUOTBEJ 6.6 IC50 2 —
UEMQPCHQAQZIOF 6.6 Ki 3 —
ZVNJVQNMVGIIHK 6.6 Ki 2 —
JNVHPQXRSAIPSE 6.6 Ki 2 —
QDCNTONXHGYVKS 6.6 Ki 2 —
WOXDRIMKYIYZMA 6.6 Ki 2 —
YZNSNVPSBDWZBQ 6.6 IC50 2 —
ACPKTBUAADMPRF 6.6 IC50 2 —
JLFYTDJGSBYOSU 6.6 Ki 2 —
MMIPUVGFRDRMQF 6.6 Ki 2 —
ZNYJUHQBBIMRAK 6.6 IC50 2 —
CONRXXQNDSIPIL 6.6 Ki 2 —
AMVNCHFDMFTEPN 6.6 IC50 3 —
JEEOSKSHTOPGLW 6.6 Ki 2 —
YZHKTAHJSVDPLB 6.6 IC50 2 —
FRWGPQGSPMCODZ 6.5 Ki 2 —
MONOMEPHEGXJGU 6.5 Ki 2 —
HGAMFPMAHINILC 6.5 IC50 4 —
YWSOBAGUHBRNMD 6.5 Ki 3 —
CFDWQBMGMQRGRG 6.5 Ki 3 —
PVDUSCJZNZYXII 6.5 Ki 2 —
OLROIDLEYZUMPK 6.5 IC50 2 —
ZVMLIIDMIWZBNT 6.5 Ki 2 —
QJTNUOZZFUWWTE 6.5 Ki 2 —
UCOUPAPCCRXGDZ 6.5 Ki 2 —
WNJGCPAHOSJXNM 6.5 Ki 2 —
FAPPNFHTSMEZSW 6.4 Ki 2 —
2D structure