Target Details
UniProt ACA3EZI9
Gene SymbolNS3
Protein NameGenome polyprotein
OrganismHepacivirus hominis
Entry Name
Organism Category Pathogen
Pfam Domains PF07652 (Flavi_DEAD) PF22027 (NS3_helicase_C) PF02907 (Peptidase_S29)
UniProt
Summary
  • Multi-target molecules 670
  • Clinical molecules 0
  • Avg pChEMBL 7.83
Top Co-occurrence Targets
  • NS4A 647 shared
  • 210 shared
  • NS3/4A 205 shared
  • 49 shared
  • 30 shared
  • 29 shared
  • ELANE 13 shared
  • 10 shared
  • CTRC 9 shared
  • 7 shared
Active Molecules (670)
InChIKey pChEMBL Type Targets Clinical
ZGGFEFUZRQSHDM 7.4 IC50 3 —
PZEWIJLQRKOFCH 7.4 IC50 2 —
KMRSRQTYTCFVAX 7.4 Ki 3 —
SXDJYVUXIXGZPI 7.4 Ki 2 —
JCCKYOXTHKQKBS 7.3 IC50 3 —
LELTXNSBXZXYHC 7.3 IC50 4 —
NHNUZULGAZMHGX 7.3 IC50 4 —
DMKDCOBBFZOCLU 7.3 Ki 2 —
QNVCYCOYQOYHKP 7.3 Ki 3 —
AHWHRKRMCIYRDN 7.3 Ki 2 —
WIKXMBXQSSPTAA 7.3 Ki 2 —
FDUWMNSSRXYVAE 7.3 Ki 2 —
OVLREHIDVJYZJD 7.3 IC50 4 —
SNJVDKQJJBRSRX 7.3 Ki 2 —
ROVUFNAGBHFCLI 7.3 IC50 2 —
UADZRUIPMPRQCM 7.3 Ki 2 —
JLTPFJDHLUJDQE 7.3 Ki 2 —
NEVFFERKSBAOKS 7.3 Ki 2 —
OCYIAXNHVLIDIT 7.3 Ki 2 —
JCPXKWWNPBKSOC 7.3 Ki 2 —
ACYQAVZVIPDFCX 7.3 IC50 4 —
HJIZQWFFDDVDRL 7.3 Ki 2 —
INZXZQOPFFWCSO 7.3 Ki 2 —
VWGQMMYCGJMUAB 7.3 IC50 4 —
YTTCIZAHXRJFOM 7.3 Ki 2 —
VARBFZKEJMFXSC 7.2 Ki 3 —
YSAPFUUTPOKROX 7.2 Ki 2 —
LBMJODLMTHMDGD 7.2 IC50 2 —
SBRBGCVJJGILOH 7.2 Ki 2 —
VNYOJACRBDECNH 7.2 IC50 2 —
XADSZCMEQSIZJY 7.2 IC50 4 —
XVYUWZNMGXPOBB 7.2 Ki 2 —
RLWINPXRBXFVPF 7.2 IC50 3 —
XJQHANQPVUYQKQ 7.2 Ki 2 —
RABUBDTVMJZNIE 7.2 Ki 2 —
VEKPHSPAMHKHOX 7.2 Ki 3 —
DAQVNZCLEDKUSD 7.2 IC50 4 —
HUYACAOSSLGCFG 7.2 IC50 4 —
SBQMQLFREOTOLJ 7.2 IC50 4 —
TUGCYOIYHXSOKI 7.2 IC50 4 —
ZKELQISUOPVZIB 7.2 IC50 4 —
FKGFJFPYHIMVIW 7.2 Ki 2 —
YCDXFXVACXODMM 7.2 IC50 2 —
CDYAGJODHXZDRE 7.2 Ki 2 —
QANSKWRZMQTBLX 7.2 IC50 4 —
RBMZJAAUGKQFBX 7.2 IC50 4 —
XGAYJOVUJFIQOJ 7.2 IC50 4 —
KKRCNFSDAPQTMV 7.2 IC50 3 —
KFPIZPYLZVHBQQ 7.1 Ki 2 —
DMXZRMUVJBHDST 7.1 IC50 4 —
2D structure