Molecule Details
InChIKeyZZUFCTLCJUWOSV-UHFFFAOYSA-N
Compound NameFurosemide
Canonical SMILESNS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL6.7
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00695
Drug NameFurosemide
CAS Number54-31-9
Groups approved investigational vet_approved
ATC Codes C03EB01 C03CA01 G01AE10 C03CB01
DescriptionFurosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.[L7958] Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failu...
Categories: Acids, Carbocyclic Amides Amines Aminobenzoates Aniline Compounds Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Benzene Derivatives Benzoates Cardiovascular Agents Diuretics Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted High-Ceiling Diuretics High-Ceiling Diuretics and Potassium-Sparing Agents Hyperglycemia-Associated Agents Hypotensive Agents Increased Diuresis at Loop of Henle Membrane Transport Modulators Natriuretic Agents Nephrotoxic agents Non Potassium Sparing Diuretics OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors Ototoxic agents Photosensitizing Agents Sodium Potassium Chloride Symporter Inhibitors Sulfanilamides Sulfonamides Sulfones Sulfur Compounds Thyroxine-binding globulin substrates UGT1A1 Substrates
Cross-references: BindingDB: 25902 ChEBI: 47426 CHEMBL35 ChemSpider: 3322 Drugs Product Database (DPD): 10091 C07017 D00331 PDB: FUN PharmGKB: PA449719 PubChem:3440 PubChem:46506779 RxCUI: 4603 Therapeutic Targets Database: DAP000043 Wikipedia: Furosemide ZINC: ZINC000000035804
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9ULX7 CA14 Homo sapiens Human PF00194 7.3 Ki ChEMBL;BindingDB
P00918 CA2 Homo sapiens Human PF00194 7.2 Ki ChEMBL;BindingDB
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 7.2 pIC50 TTD_MultiTarget
P00915 CA1 Homo sapiens Human PF00194 7.2 IC50 ChEMBL;BindingDB
P23280 CA6 Homo sapiens Human PF00194 6.6 Ki ChEMBL;BindingDB
O43570 CA12 Homo sapiens Human PF00194 6.6 Ki ChEMBL;BindingDB
Q9Y2D0 CA5B Homo sapiens Human PF00194 6.5 Ki ChEMBL;BindingDB
Q16790 CA9 Homo sapiens Human PF00194 6.4 Ki ChEMBL;BindingDB
P35218 CA5A Homo sapiens Human PF00194 6.3 Ki ChEMBL;BindingDB
P43166 CA7 Homo sapiens Human PF00194 6.3 Ki ChEMBL;BindingDB
P22748 CA4 Homo sapiens Human PF00194 6.2 Ki ChEMBL;BindingDB
DrugBank Target Actions (14)
Target Gene Target Name Action Type
P02768 ALB Albumin binder carriers
P05543 P05543 Thyroxine-binding globulin binder carriers
P52209 PGD 6-phosphogluconate dehydrogenase, decarboxylating inhibitor enzymes
P22309 UGT1A1 UDP-glucuronosyltransferase 1A1 substrate enzymes
Q9HC97 GPR35 G-protein coupled receptor 35 agonist targets
P00918 CA2 Carbonic anhydrase 2 inhibitor targets
Q13621 Q13621 Solute carrier family 12 member 1 inhibitor targets
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inducer transporters
O76082 O76082 Organic cation/carnitine transporter 2 inhibitor transporters
Q4U2R8 SLC22A6 Solute carrier family 22 member 6 inhibitor transporters
Q8TCC7 SLC22A8 Organic anion transporter 3 inhibitor transporters
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 inhibitor transporters
Q92959 SLCO2A1 Solute carrier organic anion transporter family member 2A1 inhibitor transporters
Q9NSA0 SLC22A11 Solute carrier family 22 member 11 inhibitor transporters