Molecule Details
InChIKeyZZSBPGIGIUFJRA-AKIDMACVSA-N
Compound Name(S)-3-Hydroxy Midostaurin
Canonical SMILESCO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)46
Pfam Stratification Cross-Family
Avg pChEMBL6.6
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (46)
Target Gene Organism Category Pfam pChEMBL Type Source
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 7.8 Kd ChEMBL;BindingDB
P80192 MAP3K9 Homo sapiens Human PF07714 PF14604 7.8 Kd ChEMBL;BindingDB
Q9H2K2 TNKS2 Homo sapiens Human PF00023 PF12796 PF13637 PF00644 PF07647 7.8 Kd ChEMBL;BindingDB
Q9P2K8 EIF2AK4 Homo sapiens Human PF12745 PF00069 PF05773 PF13393 7.8 Kd ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.4 Kd ChEMBL;BindingDB
Q16512 PKN1 Homo sapiens Human PF02185 PF00069 PF00433 7.2 Kd ChEMBL;BindingDB
P43405 SYK Homo sapiens Human PF07714 PF00017 7.2 Kd ChEMBL;BindingDB
P57059 SIK1 Homo sapiens Human PF00069 PF23312 7.2 Kd ChEMBL;BindingDB
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 7.2 Kd ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.2 Kd ChEMBL;BindingDB
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 7.0 Kd ChEMBL;BindingDB
O60285 NUAK1 Homo sapiens Human PF00069 7.0 Kd ChEMBL;BindingDB
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.9 Kd ChEMBL;BindingDB
Q56UN5 MAP3K19 Homo sapiens Human PF00069 6.9 Kd ChEMBL;BindingDB
P09769 FGR Homo sapiens Human PF07714 PF00017 PF00018 6.8 Kd ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 6.8 Kd ChEMBL;BindingDB
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.8 Kd ChEMBL;BindingDB
Q9Y2K2 SIK3 Homo sapiens Human PF00069 PF23312 6.6 Kd ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.6 Kd ChEMBL
Q16584 MAP3K11 Homo sapiens Human PF07714 PF14604 6.6 Kd ChEMBL;BindingDB
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 6.5 Kd ChEMBL;BindingDB
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.4 Kd ChEMBL;BindingDB
O14976 GAK Homo sapiens Human PF00069 PF10409 6.4 Kd ChEMBL;BindingDB
Q9H093 NUAK2 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.3 Kd ChEMBL;BindingDB
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.3 Kd ChEMBL;BindingDB
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Kd ChEMBL;BindingDB
Q8WTQ7 GRK7 Homo sapiens Human PF00069 PF00615 6.3 Kd ChEMBL;BindingDB
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.2 Kd ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.2 Kd ChEMBL;BindingDB
P43403 ZAP70 Homo sapiens Human PF07714 PF00017 6.2 Kd ChEMBL;BindingDB
Q13470 TNK1 Homo sapiens Human PF07714 PF22931 6.2 Kd ChEMBL;BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Kd ChEMBL;BindingDB
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 6.2 Kd ChEMBL;BindingDB
O43318 MAP3K7 Homo sapiens Human PF07714 6.1 Kd ChEMBL;BindingDB
Q13043 STK4 Homo sapiens Human PF11629 PF00069 6.1 Kd ChEMBL;BindingDB
Q8N5S9 CAMKK1 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
Q96RR4 CAMKK2 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
Q9UQB9 AURKC Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.1 Kd ChEMBL;BindingDB
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 6.0 Kd ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 Kd ChEMBL;BindingDB
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Kd ChEMBL;BindingDB
Q2M2I8 AAK1 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q9Y2U5 MAP3K2 Homo sapiens Human PF00564 PF00069 6.0 Kd ChEMBL;BindingDB
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.0 Kd ChEMBL;BindingDB