Molecule Details
| InChIKey | ZYSCOUXLBXGGIM-UHFFFAOYSA-N |
|---|---|
| Compound Name | Pf-05089771 |
| Canonical SMILES | Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 9 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.34 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB14856 |
|---|---|
| Drug Name | PF-05089771 |
| CAS Number | 1235403-62-9 |
| Groups | investigational |
| ATC Codes | nan |
| Description | PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee). |
Categories: Amides Benzene Derivatives Ethers Phenols Sulfonamides Sulfones Sulfur Compounds
Cross-references: BindingDB: 50240267 CHEMBL2325014 ChemSpider: 29411106 PDB: T70 Wikipedia: PF-05089771 ZINC: ZINC000095582552
Target Activities (9)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q01118 | SCN7A | Homo sapiens | Human | PF00520 PF24609 PF06512 | 8.0 | IC50 | ChEMBL;BindingDB |
| Q14524 | SCN5A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 8.0 | IC50 | ChEMBL;BindingDB |
| Q15858 | SCN9A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 8.0 | IC50 | ChEMBL;BindingDB |
| O60939 | SCN2B | Homo sapiens | Human | PF07686 | 7.9 | IC50 | ChEMBL;BindingDB |
| Q07699 | SCN1B | Homo sapiens | Human | PF07686 | 7.9 | IC50 | ChEMBL |
| Q99250 | SCN2A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.9 | IC50 | ChEMBL;BindingDB |
| Q9UQD0 | SCN8A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.8 | IC50 | ChEMBL;BindingDB |
| P11712 | CYP2C9 | Homo sapiens | Human | PF00067 | 6.5 | IC50 | ChEMBL;BindingDB |
| P35498 | SCN1A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.1 | IC50 | ChEMBL;BindingDB |