Molecule Details
| InChIKey | ZXAICCBFIBBVAR-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-hydroxyisoquinoline-1,3(2H,4H)-dione |
| Canonical SMILES | O=C1Cc2ccccc2C(=O)N1O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.32 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O60930 | RNASEH1 | Homo sapiens | Human | PF01693 PF00075 | 6.9 | IC50 | ChEMBL |
| Q72547 | pol | Human immunodeficiency virus type 1 | Pathogen | PF00075 PF00078 PF06815 PF06817 | 6.2 | IC50 | ChEMBL;BindingDB |
| P03433 | PA | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) | Pathogen | PF00603 | 6.1 | Ki | ChEMBL;BindingDB |
| Q9WKE8 | reverse transcriptase | Human immunodeficiency virus type 1 | Pathogen | PF00078 | 6.1 | IC50 | BindingDB |