Molecule Details
| InChIKey | ZUKXESAZGMJHLJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-methoxy-2-N-[4-(methylsulfonylmethyl)phenyl]pyrimidine-2,4-diamine |
| Canonical SMILES | COc1cnc(Nc2ccc(CS(C)(=O)=O)cc2)nc1Nc1cc(C2CC2)[nH]n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.98 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O94768 | STK17B | Homo sapiens | Human | PF00069 | 8.0 | IC50 | ChEMBL |
| Q9UEE5 | STK17A | Homo sapiens | Human | PF00069 | 7.0 | IC50 | ChEMBL |
| O43293 | DAPK3 | Homo sapiens | Human | PF00069 | 6.5 | IC50 | ChEMBL |
| P53355 | DAPK1 | Homo sapiens | Human | PF00023 PF12796 PF13637 PF00531 PF00069 | 6.4 | IC50 | ChEMBL |