Molecule Details
| InChIKey | ZRYHPQCHHOKSMD-UHFFFAOYSA-N |
|---|---|
| Compound Name | Hexocyclium |
| Canonical SMILES | C[N+]1(C)CCN(CC(O)(c2ccccc2)C2CCCCC2)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.29 |
| Source | BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06787 |
|---|---|
| Drug Name | Hexocyclium |
| CAS Number | 6004-98-4 |
| Groups | approved |
| ATC Codes | A03AB10 |
| Description | Hexocyclium is a muscarinic acetylcholine receptor antagonist which was presumably used in the treatment of gastric ulcer or diarrhea. It was once available under the tradename Tral marketed by Abbvie Inc. but has been discontinued. Proton pump inhibitors like [DB00338] and opiate anti-diarrheal age... |
Categories: Agents producing tachycardia Alimentary Tract and Metabolism Anticholinergic Agents Drugs for Functional Gastrointestinal Disorders Muscarinic Antagonists Synthetic Anticholinergics, Quaternary Ammonium Compounds
Cross-references: BindingDB: 81959 ChEBI: 5707 CHEMBL1201325 ChemSpider: 22621 C07811 PubChem:24199 PubChem:310264885 RxCUI: 26867 Wikipedia: Hexocyclium
Target Activities (4)
DrugBank Target Actions (4)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P08172 | CHRM2 | Muscarinic acetylcholine receptor M2 | antagonist | targets |
| P08173 | CHRM4 | Muscarinic acetylcholine receptor M4 | antagonist | targets |
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | antagonist | targets |
| P20309 | CHRM3 | Muscarinic acetylcholine receptor M3 | antagonist | targets |