InChIKey	ZQDWXGKKHFNSQK-UHFFFAOYSA-N
Compound Name	Hydroxyzine
Canonical SMILES	OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	7.47
Source	ChEMBL;BindingDB

DrugBank ID	DB00557
Drug Name	Hydroxyzine
CAS Number	68-88-2
Groups	approved investigational
ATC Codes	N05BB01 N05BB51
Description	Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for ...

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Categories: Anti-Anxiety Agents Antipruritics Central Nervous System Depressants Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Diphenylmethane Derivatives Histamine Agents Histamine Antagonists Histamine H1 Antagonists Histamine Receptor Antagonists Miscellaneous Anxiolytics Sedatives and Hypnotics Nervous System Neurotransmitter Agents P-glycoprotein substrates Piperazines Potential QTc-Prolonging Agents Psycholeptics QTc Prolonging Agents

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Cross-references: BindingDB: 22875 ChEBI: 5818 CHEMBL896 ChemSpider: 3531 Drugs Product Database (DPD): 8008 C07045 D08054 PharmGKB: PA449943 PubChem:3658 PubChem:46508556 RxCUI: 5553 Therapeutic Targets Database: DAP000324 Wikipedia: Hydroxyzine