Molecule Details
InChIKeyZPXSCAKFGYXMGA-UHFFFAOYSA-N
Compound NameMazindol
Canonical SMILESOC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Cross-Family
Avg pChEMBL7.34
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00579
Drug NameMazindol
CAS Number22232-71-9
Groups approved
ATC Codes A08AA05
DescriptionMazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the tre...

Categories: Adrenergic Agents Adrenergic Uptake Inhibitors Alimentary Tract and Metabolism Anorexigenic Agents & Respiratory and CNS Stimulants Anorexigenic Agents & Respiratory and Cerebral Stimulants, Miscellaneous Antidepressive Agents Antiobesity Preparations, Excl. Diet Products Central Nervous System Agents Central Nervous System Depressants Central Nervous System Stimulants Centrally Acting Antiobesity Products Combined Inhibitors of Serotonin/Norepinephrine Reuptake Dopamine Agents Dopamine Uptake Inhibitors Heterocyclic Compounds, Fused-Ring Isoindoles Membrane Transport Modulators Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators
Cross-references: BindingDB: 50005536 ChEBI: 6702 CHEMBL781 ChemSpider: 3880 Drugs Product Database (DPD): 2431 D00367 PharmGKB: PA450326 PubChem:4020 PubChem:46509094 RxCUI: 6664 Therapeutic Targets Database: DAP000722 Wikipedia: Mazindol
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
P23975 SLC6A2 Homo sapiens Human PF00209 7.9 Ki ChEMBL
Q01959 SLC6A3 Homo sapiens Human PF00209 7.6 IC50 ChEMBL
P31645 SLC6A4 Homo sapiens Human PF03491 PF00209 7.3 Ki ChEMBL
Q99720 SIGMAR1 Homo sapiens Human PF04622 6.6 IC50 ChEMBL
DrugBank Target Actions (4)
Target Gene Target Name Action Type
Q05940 SLC18A2 Synaptic vesicular amine transporter binder targets
P23975 SLC6A2 Sodium-dependent noradrenaline transporter inhibitor targets
P31645 SLC6A4 Sodium-dependent serotonin transporter inhibitor targets
Q01959 SLC6A3 Sodium-dependent dopamine transporter inhibitor targets