Molecule Details
| InChIKey | ZPXSCAKFGYXMGA-UHFFFAOYSA-N |
|---|---|
| Compound Name | Mazindol |
| Canonical SMILES | OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.34 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00579 |
|---|---|
| Drug Name | Mazindol |
| CAS Number | 22232-71-9 |
| Groups | approved |
| ATC Codes | A08AA05 |
| Description | Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the tre... |
Categories: Adrenergic Agents Adrenergic Uptake Inhibitors Alimentary Tract and Metabolism Anorexigenic Agents & Respiratory and CNS Stimulants Anorexigenic Agents & Respiratory and Cerebral Stimulants, Miscellaneous Antidepressive Agents Antiobesity Preparations, Excl. Diet Products Central Nervous System Agents Central Nervous System Depressants Central Nervous System Stimulants Centrally Acting Antiobesity Products Combined Inhibitors of Serotonin/Norepinephrine Reuptake Dopamine Agents Dopamine Uptake Inhibitors Heterocyclic Compounds, Fused-Ring Isoindoles Membrane Transport Modulators Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators
Cross-references: BindingDB: 50005536 ChEBI: 6702 CHEMBL781 ChemSpider: 3880 Drugs Product Database (DPD): 2431 D00367 PharmGKB: PA450326 PubChem:4020 PubChem:46509094 RxCUI: 6664 Therapeutic Targets Database: DAP000722 Wikipedia: Mazindol
Target Activities (4)
DrugBank Target Actions (4)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q05940 | SLC18A2 | Synaptic vesicular amine transporter | binder | targets |
| P23975 | SLC6A2 | Sodium-dependent noradrenaline transporter | inhibitor | targets |
| P31645 | SLC6A4 | Sodium-dependent serotonin transporter | inhibitor | targets |
| Q01959 | SLC6A3 | Sodium-dependent dopamine transporter | inhibitor | targets |