Molecule Details
| InChIKey | ZPHBZEQOLSRPAK-XLCYBJAPSA-N |
|---|---|
| Compound Name | Phosphoramidon |
| Canonical SMILES | CC(C)C[C@H](NP(=O)(O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.62 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB02557 |
|---|---|
| Drug Name | Phosphoramidon |
| CAS Number | 36357-77-4 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Amino Acids, Peptides, and Proteins Anti-Infective Agents Carbohydrates Enzyme Inhibitors Glycoconjugates Metalloendopeptidases, antagonists & inhibitors Peptides Protease Inhibitors
Cross-references: BindingDB: 50251742 ChEBI: 45353 CHEMBL479579 ChemSpider: 392848 C00563 PDB: RDF PubChem:445114 PubChem:46506179 Therapeutic Targets Database: DNC001121 Wikipedia: Phosphoramidon ZINC: ZINC000004475339
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P0DPD8 | EEF1AKMT4-ECE2 | Homo sapiens | Human | PF13649 PF01431 PF05649 | 8.8 | IC50 | BindingDB |
| P08473 | MME | Homo sapiens | Human | PF01431 PF05649 | 7.5 | IC50 | ChEMBL;BindingDB |
| P42892 | ECE1 | Homo sapiens | Human | PF01431 PF05649 | 7.0 | IC50 | ChEMBL;BindingDB |
| P00800 | npr | Bacillus thermoproteolyticus | Pathogen | PF07504 PF03413 PF01447 PF02868 | 7.5 | IC50 | ChEMBL;BindingDB |
| P14756 | lasB | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | Pathogen | PF07504 PF03413 PF01447 PF02868 | 7.2 | Ki | ChEMBL |