Molecule Details
InChIKeyZPAKPRAICRBAOD-UHFFFAOYSA-N
Compound NameFenbufen
Canonical SMILESO=C(O)CCC(=O)c1ccc(-c2ccccc2)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL6.14
SourceBindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08981
Drug NameFenbufen
CAS Number36330-85-5
Groups approved
ATC Codes M01AE05
DescriptionFenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, ...

Categories: Acids, Carbocyclic Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antiinflammatory and Antirheumatic Products Antiinflammatory and Antirheumatic Products, Non-Steroids Antirheumatic Agents Cyclooxygenase Inhibitors Enzyme Inhibitors Musculo-Skeletal System Nephrotoxic agents Non COX-2 selective NSAIDS Peripheral Nervous System Agents Propionates Sensory System Agents
Cross-references: BindingDB: 50240374 ChEBI: 31599 CHEMBL277522 ChemSpider: 3218 D01344 PharmGKB: PA166049176 PubChem:3335 PubChem:310264942 RxCUI: 24830 Wikipedia: Fenbufen ZINC: ZINC000000001427
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P49662 CASP4 Homo sapiens Human PF00619 PF00656 6.2 IC50 BindingDB
P55211 CASP9 Homo sapiens Human PF00619 PF00656 6.1 IC50 BindingDB
P51878 CASP5 Homo sapiens Human PF00619 PF00656 6.1 IC50 BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P23219 PTGS1 Prostaglandin G/H synthase 1 inhibitor targets
P35354 PTGS2 Prostaglandin G/H synthase 2 inhibitor targets