InChIKey	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Compound Name	Glibenclamide
Canonical SMILES	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	7.25
Source	BindingDB;ChEMBL

DrugBank ID	DB01016
Drug Name	Glyburide
CAS Number	10238-21-8
Groups	approved investigational
ATC Codes	A10BB01
Description	Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.[L8123] It is typically given to patients who cannot be managed with the standard first line therapy, [metformin].[L8123] Glyburide stimulates insulin secretion through the closure of ATP-sensitive po...

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Categories: Alimentary Tract and Metabolism Amides BCRP/ABCG2 Substrates BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Blood Glucose Lowering Agents Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs Used in Diabetes Drugs causing inadvertant photosensitivity Hypoglycemia-Associated Agents Insulin Secretagogues OAT1/SLC22A6 inhibitors OATP2B1/SLCO2B1 substrates Oral Hypoglycemics P-glycoprotein inhibitors Photosensitizing Agents Sulfones Sulfonylureas Sulfur Compounds

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Cross-references: BindingDB: 50012957 ChEBI: 5441 CHEMBL472 ChemSpider: 3368 Drugs Product Database (DPD): 4007 Guide to Pharmacology: 2414 IUPHAR: 2414 C07022 D00336 PDB: GBM PharmGKB: PA449782 PubChem:3488 PubChem:46509154 RxCUI: 4815 Therapeutic Targets Database: DAP000037 Wikipedia: Glibenclamide ZINC: ZINC000000537805