Molecule Details
InChIKeyZMZGUJSLGMATGF-UHFFFAOYSA-N
Compound NameFLT3/IRAK1/4 inhibitor NCGC2327
Canonical SMILESCOc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cn[nH]c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Cross-Family
Avg pChEMBL7.69
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 8.9 IC50 ChEMBL;BindingDB
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 8.3 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.4 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.9 IC50 ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.9 IC50 ChEMBL;BindingDB