Molecule Details
| InChIKey | ZMZGFAGXALOLIK-UHFFFAOYSA-N |
|---|---|
| Compound Name | Pde4-IN-12 |
| Canonical SMILES | COc1c(OCC2CC2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.75 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 8.5 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 8.0 | IC50 | ChEMBL |
| Q13946 | PDE7A | Homo sapiens | Human | PF00233 | 7.8 | IC50 | ChEMBL |
| O60658 | PDE8A | Homo sapiens | Human | PF00989 PF08629 PF23198 PF00233 | 6.7 | IC50 | ChEMBL |