1H-Indole-2-carboxamide, N-(4-(1-(trans-4-(4-acetyl-1-piperazinyl)cyclohexyl)-4-amino-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-

InChIKey	`ZMNWFTYYYCSSTF-UHFFFAOYSA-N`
Compound Name	1H-Indole-2-carboxamide, N-(4-(1-(trans-4-(4-acetyl-1-piperazinyl)cyclohexyl)-4-amino-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-
Canonical SMILES	`COc1cc(-c2nn(C3CCC(N4CCN(C(C)=O)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	18
Pfam Stratification	Cross-Family
Avg pChEMBL	6.97
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	9.0	Ki	ChEMBL
P12931	SRC	Homo sapiens	Human	PF07714 PF00017 PF00018	8.5	Ki	ChEMBL
P00533	EGFR	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	7.6	Ki	ChEMBL
P53667	LIMK1	Homo sapiens	Human	PF00412 PF00595 PF07714	7.5	Ki	ChEMBL
P04626	ERBB2	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	7.3	Ki	ChEMBL
Q15303	ERBB4	Homo sapiens	Human	PF00757 PF14843 PF07714 PF01030 PF21314	7.3	Ki	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.8	IC50	ChEMBL;BindingDB
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.8	Ki	ChEMBL
Q5VT25	CDC42BPA	Homo sapiens	Human	PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433	6.8	Ki	ChEMBL
Q96GD4	AURKB	Homo sapiens	Human	PF00069	6.8	Ki	ChEMBL
O14965	AURKA	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
P51955	NEK2	Homo sapiens	Human	PF00069	6.7	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.4	Ki	ChEMBL
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.4	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.4	Ki	ChEMBL
O96013	PAK4	Homo sapiens	Human	PF00786 PF00069	6.3	Ki	ChEMBL
O96017	CHEK2	Homo sapiens	Human	PF00498 PF00069	6.1	Ki	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.1	Ki	ChEMBL