Molecule Details
InChIKeyZLVOTRRGLSDLPF-UHFFFAOYSA-N
Compound Name6-{1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-indazole
Canonical SMILESc1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)36
Pfam Stratification Cross-Family
Avg pChEMBL6.54
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (36)
Target Gene Organism Category Pfam pChEMBL Type Source
P43405 SYK Homo sapiens Human PF07714 PF00017 7.5 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.5 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.3 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 7.0 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.9 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.9 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.8 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.8 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.8 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.7 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.6 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.5 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.5 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.5 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.5 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.3 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.3 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.3 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.3 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.2 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.2 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.1 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.1 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.1 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.1 Ki ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.0 Ki ChEMBL