Molecule Details
InChIKeyZIAOVIPSKUPPQW-UHFFFAOYSA-N
Canonical SMILESCn1c(Cn2ccc(C(F)(F)F)c(Oc3cc(Cl)cc(C#N)c3)c2=O)n[nH]c1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.54
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12301
Drug NameDoravirine
CAS Number1338225-97-0
Groups approved investigational
ATC Codes J05AR24 J05AG06
DescriptionDoravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disopro...

Categories: Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Substrates Direct Acting Antivirals Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor Non-Nucleoside Reverse Transcriptase Inhibitors Nonnucleoside Reverse Transcriptase Inhibitors Pyridines
Cross-references: BindingDB: 50508293 CHEMBL2364608 ChemSpider: 28424197 Drugs Product Database (DPD): 23001 PDB: 2KW PubChem:58460047 PubChem:347828567 RxCUI: 2055755 Wikipedia: Doravirine ZINC: ZINC000072317283
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9WKE8 reverse transcriptase Human immunodeficiency virus type 1 Pathogen PF00078 7.7 IC50 BindingDB
Q72547 pol Human immunodeficiency virus type 1 Pathogen PF00075 PF00078 PF06815 PF06817 7.4 IC50 ChEMBL;BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P20815 CYP3A5 Cytochrome P450 3A5 substrate enzymes
P03366 gag-pol Gag-Pol polyprotein inhibitor targets
Q72547 pol Reverse transcriptase/RNaseH inhibitor targets