Molecule Details
InChIKeyZHUJMSMQIPIPTF-IBURTVSXSA-N
Compound NameDadle
Canonical SMILESCC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL8.23
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08856
Drug NameDADLE
CAS Number63631-40-3
Groups experimental
ATC Codes nan
DescriptionA delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

Categories: Amino Acids, Peptides, and Proteins Enkephalin, Leucine Enkephalins Nerve Tissue Proteins Neuropeptides Opioid Peptides Peptides Proteins
Cross-references: BindingDB: 21025 CHEMBL340032 ChemSpider: 5292936 Wikipedia: DADLE ZINC: ZINC000014952092
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P41143 OPRD1 Homo sapiens Human PF00001 9.1 Ki ChEMBL;BindingDB
P35372 OPRM1 Homo sapiens Human PF00001 8.6 Ki BindingDB
P41145 OPRK1 Homo sapiens Human PF00001 7.0 Ki BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P41143 OPRD1 Delta-type opioid receptor agonist targets
P35372 OPRM1 Mu-type opioid receptor inhibitor targets
Q9Y6L6 SLCO1B1 Solute carrier organic anion transporter family member 1B1 binder transporters