Molecule Details
InChIKeyZHJGWYRLJUCMRT-QGZVFWFLSA-N
Compound Name5-(6-((4-Methyl-1-piperazinyl)methyl)-1H-benzimidazol-1-yl)-3-((1R)-1-(2-(trifluoromethyl)phenyl)ethoxy)-2-thiophenecarboxamide
Canonical SMILESC[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)18
Pfam Stratification Cross-Family
Avg pChEMBL6.58
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (18)
Target Gene Organism Category Pfam pChEMBL Type Source
P53350 PLK1 Homo sapiens Human PF00069 PF00659 8.7 Ki ChEMBL;BindingDB
Q9H093 NUAK2 Homo sapiens Human PF00069 7.6 Kd ChEMBL;BindingDB
O94804 STK10 Homo sapiens Human PF00069 PF12474 7.2 Kd ChEMBL;BindingDB
Q13233 MAP3K1 Homo sapiens Human PF21040 PF00069 PF04434 7.0 Kd ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.7 Kd ChEMBL;BindingDB
P11309 PIM1 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
P51955 NEK2 Homo sapiens Human PF00069 6.6 Kd ChEMBL;BindingDB
Q9UK32 RPS6KA6 Homo sapiens Human PF00069 PF00433 6.5 Kd ChEMBL;BindingDB
Q9NSY1 BMP2K Homo sapiens Human PF15282 PF00069 6.3 Kd ChEMBL;BindingDB
Q9NYY3 PLK2 Homo sapiens Human PF00069 PF00659 6.3 Kd ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.2 Kd ChEMBL;BindingDB
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.2 Kd ChEMBL;BindingDB
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.2 Kd ChEMBL;BindingDB
O75676 RPS6KA4 Homo sapiens Human PF00069 PF00433 6.1 Kd ChEMBL;BindingDB
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.1 Kd ChEMBL;BindingDB
Q99755 PIP5K1A Homo sapiens Human PF01504 6.1 Kd ChEMBL;BindingDB
P19784 CSNK2A2 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q9UQM7 CAMK2A Homo sapiens Human PF08332 PF00069 6.0 Kd ChEMBL;BindingDB