InChIKey	ZEUITGRIYCTCEM-KRWDZBQOSA-N
Compound Name	Duloxetine
Canonical SMILES	CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	12
Pfam Stratification	Cross-Family
Avg pChEMBL	6.49
Source	BindingDB;ChEMBL

DrugBank ID	DB00476
Drug Name	Duloxetine
CAS Number	116539-59-4
Groups	approved investigational
ATC Codes	N06AX21
Description	Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686.[A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.[L...

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Categories: Agents producing tachycardia Analgesics Antidepressive Agents Antidepressive Agents Indicated for Depression Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Hypoglycemia-Associated Agents Membrane Transport Modulators Nervous System Neurotransmitter Uptake Inhibitors Norepinephrine Uptake Inhibitors P-glycoprotein inhibitors Peripheral Nervous System Agents Psychoanaleptics Psychotropic Drugs Selective Serotonin Reuptake Inhibitors Sensory System Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators Serotonin and Noradrenaline Reuptake Inhibitors Sulfur Compounds Thiophenes

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Cross-references: BindingDB: 84745 ChEBI: 36795 CHEMBL1175 ChemSpider: 54822 Drugs Product Database (DPD): 20171 Guide to Pharmacology: 202 IUPHAR: 202 PDB: 29E PharmGKB: PA10066 PubChem:60835 PubChem:46507937 RxCUI: 72625 Therapeutic Targets Database: DAP000494 Wikipedia: Duloxetine ZINC: ZINC000001536779