Molecule Details
| InChIKey | ZEMLAXHMFOILNW-JOOBJXAISA-N |
|---|---|
| Compound Name | 5-[3-[(3S)-4-(4-chloro-3-fluoro-5-methoxy-phenyl)-3-methyl-piperazin-1-yl]-2-methyl-3-oxo-propyl]-5-methyl-imidazolidine-2,4-dione |
| Canonical SMILES | COc1cc(N2CCN(C(=O)[C@@H](C)C[C@@]3(C)NC(=O)NC3=O)C[C@@H]2C)cc(F)c1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.64 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9UKP5 | ADAMTS6 | Homo sapiens | Human | PF17771 PF19236 PF05986 PF01562 PF08686 PF01421 PF19030 PF00090 | 7.9 | IC50 | BindingDB |
| Q9UNA0 | ADAMTS5 | Homo sapiens | Human | PF17771 PF19236 PF05986 PF01421 PF19030 PF00090 | 7.9 | IC50 | ChEMBL;BindingDB |
| O75173 | ADAMTS4 | Homo sapiens | Human | PF17771 PF19236 PF05986 PF01421 PF00090 | 7.1 | IC50 | ChEMBL;BindingDB |