N-tert-butyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

InChIKey	`ZDPGLLQANLROFM-UHFFFAOYSA-N`
Compound Name	N-tert-butyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Canonical SMILES	`CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	6.49
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P49336	CDK8	Homo sapiens	Human	PF00069	7.5	Ki	ChEMBL
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.5	Ki	ChEMBL
Q00535	CDK5	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
Q5S007	LRRK2	Homo sapiens	Human	PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477	6.8	Ki	ChEMBL
P17612	PRKACA	Homo sapiens	Human	PF00069	6.5	Ki	ChEMBL
Q04912	MST1R	Homo sapiens	Human	PF07714 PF01437 PF01403 PF01833	6.5	Ki	ChEMBL
Q13464	ROCK1	Homo sapiens	Human	PF25346 PF00069 PF08912	6.5	Ki	ChEMBL
Q12851	MAP4K2	Homo sapiens	Human	PF00780 PF00069	6.4	Ki	ChEMBL
Q9Y463	DYRK1B	Homo sapiens	Human	PF00069	6.4	Ki	ChEMBL
P49840	GSK3A	Homo sapiens	Human	PF00069	6.3	Ki	ChEMBL
P49760	CLK2	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
P49841	GSK3B	Homo sapiens	Human	PF00069	6.2	Ki	ChEMBL
Q04759	PRKCQ	Homo sapiens	Human	PF00130 PF21494 PF00069 PF00433	6.2	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	6.2	Ki	ChEMBL
Q16620	NTRK2	Homo sapiens	Human	PF07679 PF13855 PF16920 PF01462 PF07714	6.1	Ki	ChEMBL
O96013	PAK4	Homo sapiens	Human	PF00786 PF00069	6.0	Ki	ChEMBL
Q02750	MAP2K1	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL