Molecule Details
InChIKeyZCCUWMICIWSJIX-NQJJCJBVSA-N
Compound NamePyridinium, 4-(2-(((6R,7R)-2-carboxy-7-(((2Z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)thio)-4-thiazolyl)-1-methyl-, inner salt
Canonical SMILESCCO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL6.75
SourceBindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06590
Drug NameCeftaroline fosamil
CAS Number229016-73-3
Groups approved investigational
ATC Codes J01DI02
DescriptionCeftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.

Categories: Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Cephalosporins Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents Sulfur Compounds Thiazines beta Lactam Antibiotics beta-Lactams
Cross-references: BindingDB: 50482776 ChEBI: 70718 CHEMBL501122 ChemSpider: 8028692 D08884 PubChem:9852981 PubChem:175427075 RxCUI: 1040004 Wikipedia: Ceftaroline_fosamil
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
Q53729 pbp2 Staphylococcus aureus Pathogen PF00912 PF00905 7.3 IC50 BindingDB
Q9XDB3 pbpF Staphylococcus aureus Pathogen PF03717 PF00905 7.2 IC50 BindingDB
P14677 pbpX Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Pathogen PF03793 PF03717 PF00905 6.8 IC50 BindingDB
Q53725 pbpA Staphylococcus aureus Pathogen PF03793 PF03717 PF00905 6.8 IC50 BindingDB
Q7DHH4 mecA Staphylococcus aureus Pathogen PF05223 PF03717 PF00905 6.5 IC50 BindingDB
Q04707 ponA Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Pathogen PF00912 PF00905 6.4 IC50 BindingDB
P0A3M5 penA Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Pathogen PF03717 PF00905 6.1 IC50 BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P0AEB2 P0AEB2 Penicillin-binding protein inhibitor targets